两种方案治疗老年单纯收缩期高血压的临床观察  

Contrast study of two medication therapy for senile patients with isolated systolic hypertension

作　　者：王慧华[1] 

机构地区：[1]宁国市人民医院,安徽242300

出　　处：《安徽卫生职业技术学院学报》2011年第2期26-27,29,共3页Journal of Anhui Health Vocational & Technical College

摘　　要：目的:比较两种不同抗高血压方案治疗老年单纯收缩期高血压(ISH)的降压疗效和安全性。方法:144例轻、中度老年1SH患者,随机分为联合组:给予贝那普利(10 mg)+氢氯噻嗪(12.5mg)+单硝酸异山梨酯缓释片(40 mg),晨服1次;常规组:给予贝那普利(5mg/次,2次/d),氢氯噻嗪(25 mg,1次/d)。比较两组治疗前后(8 w末)的降压疗效及生化指标变化。结果:联合组能显著降低收缩压与脉压,降压疗效联合组、常规组分别为93.1%、75.0%,两组比较差异显著(P<0.05)。两组心率及生化指标与基线值比较差异不显著(P>0.05)。结论:联合组小剂量三药联用晨服一次,能有效降低轻中度老年ISH患者的血压,降压效果大于双倍剂量常规二药联用,对代谢无明显不良影响。Objective ：To compare the efficacy and safety of two treatments of anti-hypertension for senile patients with isolated systolic hypertension（ISH）.Methods ： 144 cases with mild-to-moderate ISH were divided into two groups randomly.All of the patients in the united group were given Benazepril 10 mg,hydrochlorothiazide 12.5 mg and isosorbide mononitrate 40 mg per day in the morning.And the patients in the normal group were given Benazepril 10 mg twice a day and hydrochlorothiazide 25 mg once a day.The course of the treatment was 8 weeks.Blood pressure and biochemical indicator before and after the medicine were measured.Results ：The effect on systolic pressure and diastolic pressure was obviously in the united group.And the general efficacy of the united group and the normal group were 93.1% and 75.0% respectively.and there was significant difference between the two groups （P〈0.05）.There was no obvious difference in heart rate and biochemical indicator between the two groups （P〉0.05）. Conclusion：The therapv of small dose of captopril,isosorbide mononitrate and hydrochiorothiazide once in the morning can efficiently decrease the blood pressure of senile patients with mild- to-moderate ISH.The therapeutic effect is doubled by double doses of Benazepril and hydroehlorothiazide,which has no bad effect on metabolism.

关 键 词：老年单纯收缩期高血压抗高血压药物 

分 类 号：R544.1[医药卫生—心血管疾病]