血必净注射液对凝血功能障碍脓毒症患者的临床研究  

The Effect of Xuebijing Injection on Coagulation Dysfunction of Patients with Sepsis

作　　者：姚莉[1,2] 周小妹[1,2] 王汉明[3,4] 赵晶晶[1,2] 崔静[1,2] 王虎[1,2] 陈婷[1,2] 

机构地区：[1]安徽医科大学第四临床学院 [2]合肥市第二人民医院重症医学科,230011 [3]安徽省中医学院第一附属医院 [4]安徽省中医院普外科

出　　处：《中华全科医学》2011年第7期1032-1034,共3页Chinese Journal of General Practice

摘　　要：目的探讨血必净注射液对凝血功能障碍脓毒症患者的临床应用价值和可能的作用机制。方法将2009年1月-2010年12月合肥市第二人民医院重症医学科收治的伴有凝血功能障碍的脓毒症患者78例,按照随机数字表法分为对照组38例,治疗组40例,后者在常规治疗基础上加用血必净注射液50 ml静脉滴注,2次/d,连用7 d,分别检测两组患者治疗前及治疗7 d后凝血酶原时间(PT),活化部分凝血酶原时间(APTT),纤维蛋白原(Fib),血小板计数(PLT)等凝血指标水平,并检测C反应蛋白浓度(CRP),同时行急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)和器官功能衰竭(Marshall)评分,并记录患者ICU住院时间及28 d病死率。结果治疗7 d后两组患者凝血功能均有所好转,但治疗组较对照组改善明显(P<0.05);两组患者治疗后APACHEⅡ评分及Marshall评分均明显下降(P<0.05),但治疗组较对照组下降更明显(P<0.05);治疗组较对照组C反应蛋白浓度下降明显(P<0.05);治疗组ICU平均住院日较对照组有所缩短,但差异无统计学意义(P>0.05);对照组患者死亡8例,病死率为21.05%(8/38),治疗组死亡7例,病死率17.50%(7/40)。结论血必净注射液能够改善脓毒症患者的凝血功能,明显提高疗效,改善脓毒症患者的预后,是治疗脓毒症的临床有效药物。Objective To investigate the clinical value and possible mechanism of Xuebijing injection on coagulation dysfunction of patients with sepsis.Methods Seventy eight sepsis patients with coagulation admitted to the Intensive Care Unit from Jan.2009 to Dec.2010 were divided into control group（n=38） and therapy group（n=40） in whom 50 ml Xuebijing injection was given twice daily for 7 days besides routine therapies,according to the random numeral.Two groups of patients were detected the coagulation function indexes,including prothrombin time（PT）,activated partial thromboplastin time（APTT）,fibrinogen（Fib）,platelet count（PLT） before treatment and 7 days after treatment,C-reaction protein were determined and APACHE Ⅱ score and Marshall scores were also recorded at the same time,meanwhile,the length of stay in ICU and 28-days mortality rate was observed.Results After treatment for a week,two groups had significant difference in coagulation function indexes,APACHE Ⅱ score,Marshall score and CRP,were significantly lower（all P0.05） in therapy group compared with control group,the average hospitalization days of the ICU was shorter in therapy group compared with control group,but with no significant difference（P0.05）.Seven patients died in therapy groups while eight patients died in control group,and the 28-day mortality of the two groups was 17.50% and 21.05%,respectively.Conclusion Xuebijing injection could improve coagulation indexes in sepsis patients with coagulation dysfunction.And it could also enhance the curative effect,improve prognosis,and it had important clinical value in the treatment of sepsis.

关 键 词：血必净注射液 脓毒症 凝血功能障碍 

分 类 号：R631[医药卫生—外科学]