病毒性心肌炎患儿血清内脂素和ENA-78水平的变化  

Levels of Visfatin and ENA-78 in Serum of Children with Viral Myocarditis

作　　者：严伟强[1] 黄友敏[1] 周永勤[2] 

机构地区：[1]山东省滕州市中心人民医院输血科,277500 [2]山东省滕州市中心人民医院儿科,277500

出　　处：《中华全科医学》2011年第7期1046-1047,共2页Chinese Journal of General Practice

摘　　要：目的探讨病毒性心肌炎患儿血清内脂素和中性粒细胞激活肽-78(ENA-78)的变化及临床意义。方法采用ELISA法测定52例病毒性心肌炎患儿血清内脂素和ENA-78水平,同时检测CK-MB,并与36例健康儿童作对照。结果病毒性心肌炎急性期血清内脂素和ENA-78水平明显高于恢复期及对照组(P<0.01);恢复期内脂素和ENA-78水平与对照组比较,差异无统计学意义(P>0.05)。病毒性心肌炎患儿内脂素与ENA-78、CK-MB呈正相关(r=0.72,0.78,P<0.05),ENA-78与CK-MB亦呈正相关(r=0.84,P<0.05)。结论内脂素和ENA-78可能参与病毒性心肌炎的发生、发展,并可作为病情判断及预后的观察指标。Objective To investigate the levels of Visfatin and epithelial neutrophil-activing peptide-78（ENA-78） in serum of children with viral myocarditis and its clinical significance.Methods The serum levels of Visfatin and ENA-78 were detected by ELISA in 52 children with viral myocarditis,and 36 normal healthy children.CK-MB was also measured.Results The serum levels of Visfatin,ENA-78 and CK-MB in viral myocarditis group with the acute stage were higher than those of viral myocarditis group with recovery stage and control group（P0.01）;But there was no significant difference in the serum levels of Visfatin,ENA-78 and CK-MB between viral myocarditis group with the recovery stage and control group（P0.05）.And there was positive correlation between Visfatin and ENA-78,CK-MB（r=0.72,0.78,P0.05）;there was positive correlation between ENA-78 and CK-MB（r=0.84,P0.05）.Conclusion Visfatin and ENA-78 may play a role in the viral myocarditis pathogenesis,and there could be new prognosis factors for viral myocarditis.

关 键 词：病毒性心肌炎 内脂素 中性粒细胞激活肽-78 

分 类 号：R542.211[医药卫生—心血管疾病]