系统性红斑狼疮患者3种血清免疫因子水平检测的意义  

Clinical signficance of determination of three serum immunological factors levels in patients with SLE

作　　者：刘惠容 曾东良[2] 姜焕好[2] 刘晓燕[2] 徐惠莲[2] 

机构地区：[1]广东省惠州市惠阳区妇幼保健院,516001 [2]广东省深圳市宝安区人民医院,518101

出　　处：《检验医学与临床》2011年第11期1295-1296,共2页Laboratory Medicine and Clinic

摘　　要：目的探讨系统性红斑狼疮(SLE)患者血清中白细胞介素-6(IL-6)、IL-10、肿瘤坏死因子-α(TNF-α)的水平变化和意义。方法分别用放射免疫分析和酶联免疫吸附试验(ELISA)对26例SLE患者IL-6I、L-10、TNF-α进行检测,并与20例健康者作比较。结果 SLE患者IL-6I、L-10和TNF-α水平明显高于健康组,差异具有统计学意义(P<0.01)。结论检测SLE患者血清IL-6I、L-10、TNF-α水平的变化对SLE患者的临床诊断和临床观察有临床价值。Objective To explore the clinical signficance of the changes of serum IL-6,IL-10 and TNF-α in patients with SLE.Methods The level of TNF-α was detected by RIA,and levels of IL-6 and IL-10 were detected by ELISA in 26 patients with SLE and 20 controls.Results The levels of serum IL-6,IL-10,TNF-α in those patients with SLE were higher than those if control,the result was significantly different（P〈0.01）.Conclusion Detection of the changes in serum IL-6,IL-10 and TNF-α levels may have some clinical values in the clinical diagnosis and observation in patients with SLE.

关 键 词：系统性红斑狼疮 白细胞介素-6 白细胞介素-10 肿瘤坏死因子-Α 

分 类 号：R758.62[医药卫生—皮肤病学与性病学]