健康青年男性移居高原后血浆铜、锌、钙、镁元素含量变化及与高原习服评价的相关性研究  

Relationship between plasma concentrations of Cu,Zn,Ca and Mg and the acclimatization to high altitude

作　　者：后显华[1,2] 罗勇军[2] 蒋春华[1,2] 刘福玉[1,2] 刘燕[1,2] 杨晓红[2] 高钰琪[1,2] 

机构地区：[1]第三军医大学高原军事医学系病理生理与高原生理学教研室,重庆400038 [2]第三军医大学高原医学教育部重点实验室,重庆400038

出　　处：《国际检验医学杂志》2011年第9期929-931,共3页International Journal of Laboratory Medicine

基　　金：国家自然科学基金资助项目(30900715);国家科技支撑计划(2009BAI85B01);国家重点基础研究发展计划(2006CB504101)

摘　　要：目的探讨健康青年男性移居高原后血浆铜(Cu)、锌(Zn)、钙(Ca)、镁(Mg)元素含量变化规律及其与高原习服的关系。方法分别在1 400 m某地选取20名拟进入4 200 m高原的健康青年男性,测定其静息心率(HR)、血压(BP)、动脉血氧饱和度(SaO2),采集空腹静脉血5 mL,于0 d检测血红蛋白(Hb)浓度及Cu、Zn、Ca、Mg元素含量。跟踪该20名男性到达4 200 m高原,分别在到达高原后7、30 d时再测定其上述指标。同时选取职业、年龄相匹配的20名从平原移居4 200 m高原90 d的健康男性,测定其上述指标。结果移居高原后血浆Cu元素无显著变化;移居高原后30、90 d血浆Zn元素含量显著低于0、7 d(P<0.05);90 d血浆Ca元素含量显著低于0、7 d(P<0.05);90 d血浆Mg元素含量显著低于0、7、30 d(P<0.05)。移居高原7 d血浆Zn元素含量与高原习服评价指标HR呈线性负相关(r=-1.137,P<0.05)。结论移居高原后,血浆Zn、Ca和Mg元素含量发生显著变化。在高原习服过程中要注意合理补充Zn、Ca和Mg元素。Objective To explore the relationship between plasma concentrations of Cu,Zn,Ca and Mg and the degree of acclimatization to high altitude, so as to provide experimental basis for rational supplementation. Methods 20 healthy young men were enrolled and detected for heart rate（HR）,blood pressure（BP）,arterial oxygen saturation（SaO2 ）,hemoglobin（Hb） and plasma concentrations of Cu,Zn,Ca and Mg,when they stayed in regions with altitude about 1 400 m and 7 and 30 clays after migrated to re gions with altitude above 4 200 m. Another 20 healthy young men,with matching job and age,who had migrated to 4 200 m for 90 days were also detected for all indexed mention above. Results There was no significant change of plasma concentration of Cu after ascending to high altitude. Plasma concentration of Zn detected at the 30th and 90th day was significantly lower than detected before migration and at the 7th day after migration（P〈0.05）. Plasma concentration of Ca detected at the 90th day was significantly lower than detected before migration and at the 7th day after migration（P〈0.05）. Plasma concentration of Mg detected at the 90th day was significantly lower than detected before migration and the 7th and 30th day after migration（P〈0.05）. There was a negative correlation between plasma concentration of Zn （the 7th day）and HR（the 7th day） （r= -1. 137 ,P〈0.05）. Conclusion Under hypoxic stress, there were significant changes of the plasma concentration of Ca, Mg and Zn. Extra supplementation of Ca, Mg and Zn is required for high altitude acclimatization.

关 键 词：铜 锌 钙 镁 高原习服 

分 类 号：R594.3[医药卫生—内科学]