阿司匹林联合不同的抗凝剂对川崎病炎性细胞因子的影响  

Aspirin and Different Anticoagulant Agent on the Levels of Serum Inflammatory Cytokines in Kawasaki Disease

作　　者：张庆[1] 李晓静[2] 史宏[2] 周敏[2] 徐鸣[2] 黄成[2] 王雪梅[2] 王献民[2] 于洁[1] 

机构地区：[1]重庆医科大学附属儿童医院,重庆400014 [2]成都市儿童医院,成都610017

出　　处：《血栓与止血学》2011年第3期115-117,共3页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的检测在不同的治疗方案下川崎病患儿治疗前后血清IL-6、IL-8、TNF-α水平的变化,观察阿司匹林联合不同抗凝剂对川崎病血清炎性细胞因子的影响。方法将住院的92例川崎病患儿随机分为：丹参酮ⅡA治疗组、肝素治疗组和常规治疗组,并与19名健康体检儿童作对照。采用双抗体酶联免疫吸附法（ELISA）检测患儿治疗前后血清IL-6、IL-8、TNF-α水平。结果川崎病患儿治疗前血清IL-6、IL-8、TNF-α水平均较正常对照组升高,治疗后5~7 d血清IL-6、IL-8和TNF-α水平均明显下降,其中丹参酮ⅡA治疗组血清IL-6水平降低更明显,肝素治疗组血清TNF-α水平降低明显,差异均有统计学意义（P〈0.05）。结论丹参酮ⅡA和肝素可以一定程度地降低川崎病患儿血清IL-6和TNF-α水平;与阿司匹林和静脉丙种球蛋白在抗炎性细胞因子方面具有协同作用。Objective To study the levels of serum IL-6,IL-8 and TNF-α,in different treatment for patient with Kawasaki disease.And to investigate the treatment effect of aspirin and different anticoagulant agent on patient with Kawasaki disease.Methods 92 patient with Kawasaki disease and 19 healthy children as contral were recruited in the study.The patient with Kawasaki disease were randomly divided into three groups：Tan ⅡA,heparin and conventional therapy.Serum IL-6,IL-8,TNF-α levels were detected by ELISE method.Results The levels of serum IL-6,IL-8,TNF-α were increased before treatment,and decreased after treatment 5~7 days.The levels of serum IL-6 in the group of Tan ⅡA and serum TNF-α in the group of heparin decreased significantly than those in the group of conventional therapy after treatment 5~7 days（P0.05）,the different is statistic significant.Conclusion Tan ⅡA and heparin can decrease the levels of serum IL-6 and TNF-α,have synergetic effect with aspirin and IVIg on anti-inflammatory.

关 键 词：川崎病 炎性细胞因子 丹参酮ⅡA 肝素钠 

分 类 号：R725.4[医药卫生—儿科]