肝素治疗急性冠脉综合征时aPTT的监测作用  

The Application of Activated Partial Thromboplastin Time in the Monitor of Therapeutic Effect of Heparin in Acute Coronary Syndrome

作　　者：曾子杰 罗文英[1] 陈璐[2] 

机构地区：[1]湖南省洞口县人民医院,邵阳422300 [2]中南大学湘雅医学院

出　　处：《血栓与止血学》2011年第4期177-178,共2页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的探讨活化部分凝血活酶时间（aPTT）在急性冠脉综合征（ACS）使用普通肝素（UFH）抗凝治疗监测中的价值。方法采用监测aPTT以调整UFH的剂量,实现UFH治疗剂量标准化。结果第一次采血达标者32人（26.0%）,第二次达标者89人（72.4%）,第三次达标者121人（98.4%）,均未出现严重出血并发症。结论 UFH抗凝中最重要的是剂量调整和监测,而目前的aPTT经典范围50~70 s并没有考虑个体差异和检测系统的不同,通过标准化的剂量调整和配套的检测系统,有助规范临床治疗行为,达到理想的治疗效果。Objective To investigate the value of aPTT in the monitor of anticoagulant treatment effect of heparin in acute coronary syndrome.Methods Adjust the dose of heparin according to aPTT,to achieve the standardization of treatment dosage.Results 32（26.0%） patients reach the standard in the first blood samples,89 in the second samples,121 in the third samples.No serious bleeding complications were seen in all patients.Conclusion The most impotent part of the anticoagulant treatment is the dose adjustment and monitor.The current normal range of aPTT,which is 50 to 70 seconds,couldn′t fit the individual difference and the detecting system change.The standardization of dosage and supporting detecting system help standardizing the clinic behavior and reach the idea effect.

关 键 词：急性冠脉综合征 肝素 活化部分凝血活酶时间 

分 类 号：R543.31[医药卫生—心血管疾病]