Efficient synthesis and biological evaluation of 4-arylcoumarin derivatives  

作　　者：Jie Sun Wei Xian Ding Ke Yun Zhang Yong Zou 

机构地区：[1]Guangzhou Institute of Chemistry,Chinese Academy of Sciences,Guangzhou 510650,China [2]Department of Zoology,College of Life Sciences,Nanjing Agricultural University,Nanjing 210095,China [3]Graduate School of the Chinese Academy of Sciences,Beijing 100039,China

出　　处：《Chinese Chemical Letters》2011年第6期667-670,共4页中国化学快报（英文版）

基　　金：We thank the Science and Technology Program of Guangdong Province,Strategic Cooperation Program between Guangdong Province and Chinese Academy of Sciences and National Key Technology R&D Program,China(Nos. 2003B31603,2006B35604002,2009B091300125 and 2007BAD82B02) for financial support

摘　　要：Two bioactive natural 4-arylcoumarins,5,7,4＇-trimethoxy-4-phenylcoumarin（1a）,5,7-dimethoxy-4-phenylcoumarin（1b） and five closely related derivatives 1c-g were synthesized.In vitro evaluation with a catechol subunit for antioxidant and antimicrobial activity,these compounds using standard methods showed that compounds 1d,1f displayed promise radical scavenging activity and 1f was found to be the most active one against Bacillus dysenteriae.Two bioactive natural 4-arylcoumarins,5,7,4＇-trimethoxy-4-phenylcoumarin（1a）,5,7-dimethoxy-4-phenylcoumarin（1b） and five closely related derivatives 1c-g were synthesized.In vitro evaluation with a catechol subunit for antioxidant and antimicrobial activity,these compounds using standard methods showed that compounds 1d,1f displayed promise radical scavenging activity and 1f was found to be the most active one against Bacillus dysenteriae.

关 键 词：4-Arylcoumarin SYNTHESIS ANTIMICROBIAL ANTIOXIDANT 

分 类 号：TQ252.4[化学工程—有机化工] X826[环境科学与工程—环境工程]