An efficient method for the N-arylation of phenylurea via copper catalyzed amidation  

作　　者：Sandip N.Gavade Ravi S.Balaskar Madhav S.Mane Pramod N.Pabrekar Murlidhar S.Shingare Dhananjay V.Mane 

机构地区：[1]Organic Research Laboratory S.C.S.College,Omerga-413 606,MS,India [2]V.G.Vaze College Mulund(E),Mumbai-400081,MS,India [3]Department of Chemistry Dr.Babasaheb Ambedkar Marathwada University

出　　处：《Chinese Chemical Letters》2011年第6期675-678,共4页中国化学快报（英文版）

基　　金：Authors are thankful to Head of Department of Chemistry V.G.Vaze College,Mulund(E),Mumbai-81(MS),India and Head of Department of Organic Research Laboratory,S.C.S.College,Omerga-413 606(MS),India for providing the necessary laboratory facilities

摘　　要：The coupling reaction of phenylurea with different functionalized aryl halides in the presence of air stable CuI,N,N-dimethylethylenediamine as a ligand,and K_3PO_4 as a base gives symmetrical and unsymmetrical diarylureas in relatively high yields.This method is milder than the palladium catalyzed arylation and avoids the use of toxic phosphine ligands.The coupling reaction of phenylurea with different functionalized aryl halides in the presence of air stable CuI,N,N-dimethylethylenediamine as a ligand,and K_3PO_4 as a base gives symmetrical and unsymmetrical diarylureas in relatively high yields.This method is milder than the palladium catalyzed arylation and avoids the use of toxic phosphine ligands.

关 键 词：Copper catalyst UREA Aryl halides AMIDATION 

分 类 号：O621.25[理学—有机化学]