加兰他敏对间歇性低氧引起的认知损害的预防作用  

Effects of Galantamine in Prevention of Cognitive Impairment Induced by Intermittent Hypoxia

作　　者：李祥云[1] 唐婷[1] 热不开提.地里夏提 邓水香[1] 黄延焱[1] 

机构地区：[1]复旦大学附属华山医院老年科,上海200040

出　　处：《现代生物医学进展》2011年第13期2413-2415,共3页Progress in Modern Biomedicine

摘　　要：目的:探究加兰他敏对间歇性低氧引起的认知损伤是否有保护作用,从而说明其对睡眠呼吸暂停综合症引起的认知损害是否有预防作用。方法:建立间歇低氧大鼠模型,行水迷宫试验检测行为功能变化,免疫组化检测海马神经元及胶质细胞数目的变化。结果:加兰他敏与间歇低氧模型组相比,行水迷宫的平均逃避潜伏期缩短,游泳总距离减少;免疫组化的结果海马神经元的数目有所增加,胶质细胞的数目减少。结论:加兰他敏对间歇性低氧引起的认知损伤有明显的改善作用,可能与减少神经元的丢失及减少胶质细胞的再生有关。所以对于诊断了睡眠呼吸暂停综合征(ASA)的患者,如果同时合并其他痴呆的易感因素,可预防性应用加兰他敏。Objective：To investigate ifgalantamine has a protective effect on cognitive impairment caused by intermittent hypoxia, which indicates if it has a preventive effect on cognitive impairment caused by sleep apnea syndrome. Methods：A rat model of intermittent hypoxia was established; the water-maze test was for detection of changes in behavior; hippocampal neurons and glial cell number changes was detected by immunohistochemistry. Results： Galantamine compared with the intermittent hypoxia model, in water-maze test, the average escape latency and the total swimming distance decreased; the results of immunohistochemistry, the number of neurons increased, reducing the number of glial cells, Conclusion： Galantamine has a significant improvement for cognitive function damage induced by intermittent hypoxia, which may concern with reducing the loss of neurons and reducing the regeneration of glial cells. So for the diagnosis of sleep apnea syndrome （ASA） of the patients, if at the same time combined with other dementia risk factors, may prophylactic use of galantamine.

关 键 词：加兰他敏 睡眠呼吸暂停综合征 间歇性低氧 

分 类 号：Q95-3[生物学—动物学] R56[医药卫生—呼吸系统]