开同对维持性血液透析患者营养及脂质代谢的影响  

Effect Of Nutrition and Lipid Metabolism in Maintenance Hemodialysis Patients Treated With α-keto Acids

作　　者：李远[1] 董晓辉 邹作君[1] 

机构地区：[1]青岛大学医学院附属青岛市立医院血液净化中心,山东青岛266001 [2]胶州市人民医院肾内科,山东青岛266001

出　　处：《现代生物医学进展》2011年第13期2528-2531,共4页Progress in Modern Biomedicine

摘　　要：目的:研究复方α-酮酸对维持性血液透析(MHD)患者营养及脂质代谢的影响。方法:将40例MHD患者随机分为两组:(1)实验组(n=20),予常规蛋白饮食,并服用复方α-酮酸12片/d(;2)对照组(n=20),予常规蛋白饮食,不服用复方α-酮酸。分别于治疗前、治疗后3个月后测定各项血生化指标及人体测量学指标。结果:经3个月治疗后,实验组血白蛋白、前白蛋白较前明显升高(P<0.01),总胆固醇和甘油三酯明显下降(P<0.01),血红蛋白无明显变化(P>0.05);对照组血红蛋白、血白蛋白、前白蛋白及血脂无明显变化;实验组及对照组治疗前后体重指数、肱三头肌皮褶厚度、上臂肌围无明显变化(P>0.05)。结论:复方α-酮酸可有效改善维持性血液透析患者营养状况以及脂质代谢,但长期使用该疗法的疗效和安全性有待于进一步的研究。Objective： To explore the effect of nutrition status and lipid metabolism in maintenance hemodialysis patients treated With compound a -keto acids. Methods： 40 hemodialysis patients were divided into two groups： （1）experimental group （n=20）, were treated with common protein diet and α-keto acids 12/d α-keto acids; （2）control group （n=20）, were treated with common protein diet and without α-keto acids. Measure the biochemical parameters and anthropometry measurements before and after the three months＇ treatment. Results： After three months＇ treatment, the concentrations of albumin, pro-albumin were higher in experimental group （P 〈 0.01） and cholesteral, triglyceride decreased （P 〈0.01） significantly, there was no significant changes of hemoglobin. Meanwhile there was no significant changes of hemoglobin, albumin, pro-albumin, cholesteral and triglyceride in control group. No significantdifference existed in body mass index, triceps skinfold, middle arm muscle circumference of the two groups before and after the treatment. Conclusion： The nutritional status and lipid metabolism of maintenance hemodialysis patients could be improved after treated with α-keto acids, but the further study is expected to testify the efficacy and safety of long-term treatment.

关 键 词：复方Α-酮酸 血液透析 营养状况 脂质代谢 

分 类 号：R459.3[医药卫生—治疗学] R459.5[医药卫生—临床医学]