壳聚糖-O-聚(寡聚乙二醇甲基丙烯酸酯)的原子转移自由基聚合与表征  

Chitosan-O-Poly(oligo(ethylene glycol) methacrylate) Brush Polymers:ATRP Synthesis and Characterization

作　　者：康承军[1] 涂克华[1] 王利群[1] 蒋宏亮[1] 

机构地区：[1]浙江大学高分子科学与工程学系,杭州310027

出　　处：《功能高分子学报》2011年第2期164-169,共6页Journal of Functional Polymers

基　　金：国家自然科学基金(20774081);浙江省教育厅科研项目(Y200804954)

摘　　要：基于原子转移自由基聚合(ATRP)和十二烷基硫酸钠(SDS)-壳聚糖(CS)复合物(SCC)的位置选择性改性策略,合成了结构可控的壳聚糖-O-聚(寡聚乙二醇甲基丙烯酸甲酯)(CS-POEGMA)刷状衍生物。通过在SCC的羟基上引入溴代异丁酸后脱除SDS得到大分子引发剂O-溴化壳聚糖(CS-Br)。用红外光谱(FT-IR)与核磁共振(1H-NMR)表征了产物结构。结果表明:改变溴代度(DS)可调节聚(寡聚乙二醇甲基丙烯酸甲酯)(POEGMA)的接枝度,而改变寡聚乙二醇甲基丙烯酸甲酯(OEGMA)与CS-Br的投料比可调控POEGMA接枝链的长度。Chitosan-derived brush polymers with well-defined chemical structure were synthesized by combining ATRP with sodium dodecyl sulphate-chitosan complex（SCC）-based regioselective modification strategy.ATRP macromolecular initiator,O-bromobutyrated CS（CS-Br）,was conveniently prepared by grafting bromoisobutyrate onto the hydroxy groups of SCC and subsequently removing SDS from the O-bromobutyrated SCC.The structure of product was characterized by FT-IR and 1H-NMR.Results showed that the grafting level of POEGMA could be adjusted by varying the degree of substitution（DS） of bromobutyrate.By changing molar feeding ratio of OEGMA to CS-Br,the degree of polymerization of POEGMA could be modulated.

关 键 词：壳聚糖 原子转移自由基聚合 聚乙二醇改性 刷状聚合物 

分 类 号：O63[理学—高分子化学]