玉屏风颗粒治疗过敏性鼻炎的实验研究  

Experimental study of Yupingfeng Granule on allergic rhinitis in rat and guinea pig

作　　者：文洁[1] 朱建梅[1] 李婕[1] 袁广明[2] 向飞军[3] 

机构地区：[1]中山大学药物开发中心,广东广州510080 [2]中山大学中山医学院,广东广州510080 [3]广东环球制药有限公司,广东顺德528000

出　　处：《中成药》2011年第6期934-937,共4页Chinese Traditional Patent Medicine

摘　　要：目的观察玉屏风颗粒(黄芪、白术和防风)治疗过敏性鼻炎的药效作用。方法建立卵蛋白致大鼠及豚鼠过敏性鼻炎模型,并观察玉屏风颗粒对过敏性鼻炎症状的改善作用;通过大鼠被动皮肤过敏实验测定IgE效价,并观察药物对大鼠鼻黏膜病理学变化的影响。结果 1.对过敏性鼻炎大鼠连续用药7 d,大鼠IgE抗体水平降低,抗血清样本呈阴性;连续用药14 d,可以明显改善大鼠过敏鼻炎症状,与模型组比较P<0.01。2.对豚鼠过敏性鼻炎模型连续给药10 d后,玉屏风颗粒组症状好转率﹥80%;玉屏风颗粒治疗组鼻黏膜的嗜酸细胞增多,鼻黏膜溃疡、腺体增生以及充血水肿等病理学改变得到明显改善(P<0.05)。结论玉屏风颗粒对过敏性鼻炎大鼠和豚鼠具有良好的抗过敏作用。AIM To study effects of Yupingfeng Granule（Atragali Radix,Astractylodis macrocephalae Rhizoma,and Saposhnikoviae Radix） on allergic rhinitis in rat and guinea pig.METHODS Establishing guinea pig and rat allergic rhinitis models by repeating sensitization with ovalbumin,the improvement was observed of allergic rhinitis symptoms and the nasal pathologic changes after being treated with Yupingfeng Granule;the titer of specific IgE was measured in the rat homologous passive cutaneous anaphylaxis model.RESULTS 1.IgE antibody levels in rats were markedly decreased and the anti-serum samples became negative in rats treated with Yupingfeng Gra-nule in seven days,and the symptom of allergic rhinitis was significantly improved in rats treated with Yupingfeng Granule for fourteen days（P0.01）.2.Compared with the model group in guinea pigs,the symptomatic improvement rate was more than 80% in guinea pigs in ten days.In addition,eosinophils in the nasal mucosal were increased,and other pathological changes including the nasal mucosa erosion,glandular hyperplasia and congestive edema were significantly improved in the guinea pigs.CONCLUSION Yupingfeng Granule has significant anti-allergic effect on allergic rhinitis in rat and guinea pig.

关 键 词：过敏性鼻炎 被动皮肤过敏(PCA) IGE 玉屏风颗粒 

分 类 号：R285.5[医药卫生—中药学]