栽培灯盏花提取物的药效学研究  

Pharmacodynamic study of the extract from cultured Erigeron Breuiscapus

作　　者：苏梅 杨和金 崔涛 杨宏博 赵春梅 杨生元 

机构地区：[1]云南省药物研究所,云南昆明650111

出　　处：《中成药》2011年第6期938-943,共6页Chinese Traditional Patent Medicine

摘　　要：目的研究栽培灯盏花提取物对脑缺血、心肌缺血的影响。方法采用栓线法制备大鼠局灶性脑缺血损伤模型和大鼠冠状动脉结扎致心肌缺血损伤模型,来观察栽培灯盏花提取物对脑缺血、心肌缺血的影响。结果栽培灯盏花提取物灌胃给药,连续8 d,在60、40 mg/kg的剂量下能显著改善脑缺血大鼠受损的神经功能障碍和脑梗死面积,能显著降低缺血脑组织中MDA的含量和提高SOD、GSH-Px活性。在60、40、20 mg/kg的剂量下对冠状动脉结扎大鼠心电图ST段的抬高有不同程度的降低作用,能显著缩小心肌的梗死范围和降低血清中CK-MB和LDH的活性。结论栽培灯盏花提取物对实验性大鼠脑缺血和急性心肌梗死损伤具有显著的保护作用,且其保护作用优于同等剂量的灯盏花素片。AIM To study the effect of extract from cultured Eriger on breviscapus（Vant.）Hand.Mazz on both cerebral ischemia and myocardial ischemia of rats.METHODS Rat model for focal cerebral ischemic and myocardial ischemic were replicated by string occlusion and coronary artery occlusion,respectively,then the influence of（fleabane） extract on both was determined.RESULTS The rats were orally administered with the（fleabane） extract for 8 days.The results showed that neurological deficit and brain infarction area resulted from cerebral ischemia in rat were improved significantly,meanwhile the content of anti-oxidative enzymes and malondialdehyde was decreased significantly and the activity of both superoxide dismutase and glutathione peroxidase was increased significantly in the tissue of cerebral ischemia in dose of 60 mg/kg and 40 mg/kg.In dose of 60 mg/kg,40 mg/kg and 20 mg/kg,ST-segment elevation of electrocardiogram induced by coronary artery occlusion of rats was decreased to a certain degrees,and myocardial infarction size and the activity of both creatine phosphokinase isoenzyme and lactate dehydrogenase isozymes in blood serum were all obvious on the low side.CONCLUSION The extract from cultured Erigeron breviscapus（Vant.）Hand.Mazz had a notablely protective effects on cerebral ischemia and acute myocardial infarction,that was slightly superior to the same dose of breviscapinun tablet.

关 键 词：栽培 灯盏花提取物 脑缺血 心肌缺血 大鼠 

分 类 号：K966[历史地理—人文地理学]