肝脏发育过程中转录因子的调控  

Regulation of transcription factor during liver development

作　　者：王敏君[1] 陈费[1] 向导[1] 刘长城[1] 何志颖[1] 王欣[2] 胡以平[1] 

机构地区：[1]第二军医大学细胞生物学教研室,上海200433 [2]中国科学院上海生命科学研究院生物化学与细胞生物学研究所,上海200031

出　　处：《生命的化学》2011年第3期395-400,共6页Chemistry of Life

基　　金：国家973计划(2010CB945602);国家自然科学基金项目(30801115)资助

摘　　要：肝脏的发育经历了一系列内胚层和中胚层之间复杂的相互作用,其中转录因子扮演着重要角色。肝脏发育主要可分为两个阶段,首先是前肠内胚层感受心脏中胚层的信号而建立"响应态(competence)",肝向特化基因逐渐表达并形成新生肝芽。此阶段受到转录调控网络的控制,其中FoxA家族,锌指结构转录因子GATA4/6,同源结构域因子Hhex、Onecut1、Onecut2和Prox1发挥了重要的作用。其次是肝脏内细胞群体如肝细胞和胆管细胞的分化成熟阶段。这个过程的完成主要受肝富集转录因子HNF1α、HNF4、HNF6和C/EBPα的调控。本文概述了肝脏发育中复杂的转录调控网络及其发挥的作用。Liver development comprises a series of reciprocal interactions between embryonic endoderm and nearby mesoderm,and it is known that transcription factors play important roles in this process.Liver development mainly includes two stages.The first stage is the establishment of competence in the foregut to respond to signals from cardiac mesoderm.After the foregut closure,the endoderm cells are specialized to hepatic development,and thereafter the liver bud formed under the influence of transcriptional networks including FoxA family,zinc finger transcription factor GATA4/6,homeodomain factor Hhex,Onecut1,Onecut2 and Prox1.The second stage is the differentiation and maturation of hepatocytes and cholangiocytes.In this stage,the cellular responses to inductive signals is regulated by liver enriched transcription factors including CCAAT/enhancer binding protein（C/EBP）,hepatic nuclear factor 1（HNF-1）,HNF-4 and HNF-6.This review summarizes the complex networks of transcription factors in the regulation of liver development.

关 键 词：肝脏发育 转录因子 肝细胞 胆管细胞 

分 类 号：Q954.48[生物学—动物学]