snoRNP的生物发生  

The biogenesis of snoRNPs

作　　者：胡乐林[1] 余新超[1] 

机构地区：[1]安徽理工大学医学院,淮南232001

出　　处：《生命的化学》2011年第3期410-414,共5页Chemistry of Life

摘　　要：核仁小核糖核蛋白体颗粒(small nucleolar ribonucleoproteins partical,snoRNP)是一种定位于核仁的复合物,它由一系列核仁小RNA(small nucleolar RNA,snoRNA)和核心蛋白质结合而成。这些snoRNP指导核糖体RNA(rRNA)前体的加工修饰,在核糖体的生物发生中起着重要的作用。研究显示大多数snoRNP加工和组装的早期阶段发生在核浆,在Cajal小体(Cajal body,CB)中组装成熟之后,在PHAX、p50、p55、SMN和Nopp140等蛋白质的帮助下穿越各种不同的核间隔转运至核仁,并在核仁中发挥功能。本文对snoRNP的生物发生过程作一综述。Small nucleolar ribonucleoprotein particals （snoRNPs） are nucleolus-localised complexes consisiting of small nucleolar RNAs （snoRNAs） and several core proteins. They guide the processing and modification of pre-ribosomal RNA and play crucial roles in the ribosomal biogenesis. Recent studies have revealed that early steps in the processing and assembly of most snoRNPs occur in the nucleoplasm, and the assembly of snoRNPs is completed in Cajal bedyes （CBs）. After that, they traffic through different nuclear compartments to nucleolus assisted by addition proteins： p50, p55, SMN and Nopp140. They play important roles in nucleolus. This paper will make a summary on the biogenesis of snoRNPs.

关 键 词：核仁小核糖核酸 核仁小核糖核蛋白体颗粒 Cajal小体 非特异的核小RNA 

分 类 号：Q243[生物学—细胞生物学]