抗结核药物致肝损害与CYP2E1基因多态性  

Meta-analysis on relationship between polymorphisms of CYP2E1 gene and susceptibility to antituberculosis drug-induced liver injury

作　　者：向阳[1] 孙凤[2] 詹思延[2] 

机构地区：[1]新疆医科大学公共卫生学院流行病学与卫生统计学教研室,新疆乌鲁木齐830011 [2]北京大学公共卫生学院流行病与卫生统计学系

出　　处：《中国公共卫生》2011年第7期910-913,共4页Chinese Journal of Public Health

基　　金：国家自然科学基金(30960328)

摘　　要：目的探讨抗结核药物致肝损害(ATLI)易感性与代谢酶基因(CYP2E1基因)多态性的关系。方法采用Meta分析的方法,对国内外公开发表的有关CYP2E1基因多态性与ATLI易感性的关系的研究文献进行综合定量再分析,根据资料异质性检验决定采用随机效应模型或固定效应模型计算合并OR值。发表偏倚用失安全数法估计。结果共纳入国内外研究文献5篇,累计肝损害组194例,对照组639人,CYP2E1c1/c1基因型与ATLI易感性关系之间的合并OR值为1.86(95%CI=0.95～3.66),排除1篇研究对象为儿童的文献,合并OR值为2.22(95%CI=1.51～3.26)。结论 ATLI易感性与CYP2E1基因多态性无关;但携带CYP2E1c1/c1基因型的成人结核病患者发生肝损害的危险性可能会增加。Objective To study the relationship between the polymorphisms of CYP2E1 gene and the susceptibility to antituberculosis drug-induced liver injury.Methods A meta-analysis was performed to estimate the relationship between the polymorphisms of cytochrome 2E1（CYP2E1） gene and the susceptibility to antituberculosis drug-induced liver injury（ATLI） based on relevant epidemiological papers published domestically and abroad.Random effect model or fixed effect model analysis was used to calculate the pooled odds ratio（OR）.Publication bias was evaluated by fail-safe number（Nfs）.Results A total of 194 cases and 639 controls from 5 studies were included.The pooled OR with 95% confidence interval（CI） of ATLI risk associated with CYP2E1 homozygous wild genotype（c1/c1） was 1.86（95%CI：0.95-3.66）.After excluding the results of a survey among children,the pooled OR was 2.22（95%CI=1.51-3.26）.Conclusion The results do not support the association between the polymorphisms of CYP2E1 gene and the susceptibility to antituberculosis drug-induced liver injury,but the adult patients carring CYP2E1 c1/c1 genotype might be associated with the increased risk of ATLI.

关 键 词：代谢酶基因(CYP2E1) 基因多态性 抗结核药物所致肝损害(ATLI) Meta分析 

分 类 号：R966[医药卫生—药理学]