甲状腺功能亢进症患者药物治疗过程中不良反应临床观察  

Side effect of the antithyroid drugs on patients with hyperthyroidism

作　　者：王青平[1] 殷丽[1] 王娟娟[1] 付怀云[1] 

机构地区：[1]山西省地方病防治研究所,山西临汾041000

出　　处：《中国热带医学》2011年第6期760-761,共2页China Tropical Medicine

摘　　要：目的观察抗甲状腺药物的不良反应。方法对640例口服抗甲状腺药物治疗的Graves病患者的临床资料进行回顾性分析。结果经抗甲状腺药物治疗的640例患者中,32例发生了药物不良反应,不良反应的发生率为5.0%。其中12例发生了单一不良反应,20例发生了两种或两种以上不良反应。不良反应的发生与患者年龄、性别无关,与初诊还是复发无关。不良反应主要出现在开始治疗的3个月之内(65.6%)。不良反应以皮肤反应最为常见,其次是肝功能受损和白细胞减少。他巴唑较丙基硫氧嘧啶更容易引起皮肤反应(P<0.05)。结论 Graves病患者口服抗甲状腺药物治疗过程中,特别是开始治疗的3个月之内应重视药物不良反应的发生。Objective To observe the side effects of antithyroid drugs. Methods Clinical data of 640 cases of patients with Graves treated with antithyroid drugs were retrospectively analyzed. Results Side effects occurred in 32 cases of patients among 640 patients. Its incidence rate was 5.0%. Single side effect occurred in 12 cases of patients and more than two side effects in 20 cases of patients. The prevalence seemed to be independent of the age of the patients and of the gender and of the first diagnosis or recurrence. Side effects occurred with in 3 months after starting treatment. The main side effect was allergic reaction of skin. Secondly leucopenia and hepatotoxicity. Allergic reaction of skin was more common in patients treated with MMI than PTU （P〈0.05）. Conclusions side effects should be timely observed in patients with Graves during treatment with antithyroid drugs.

关 键 词：GRAVES病 抗甲状腺药物 不良反应 

分 类 号：R518.1[医药卫生—内科学]