神经激肽B受体在猫三叉神经脊束核尾侧亚核和脊髓内的分布  

DISTRIBUTION OF NEUROKININ B RECEPTOR (NK 3) IN THE CAUDAL SPINAL TRIGEMINAL NUCLEUS AND SPINAL CORD OF THE CAT

作　　者：吕葆真[1] 丁玉强[1] 王丹[1] 张淼丽[1] 

机构地区：[1]第四军医大学解剖学教研室

出　　处：《解剖学报》1999年第3期197-198,I002,共3页Acta Anatomica Sinica

基　　金：国家自然科学基金

摘　　要：目的了解神经激肽Ｂ受体（ＮＫ３受体）与伤害性信息的传递和调制的可能关系，调查ＮＫ３受体在三叉神经尾侧亚核和脊髓内的分布状况。方法免疫组织化学技术。结果ＮＫ３受体样免疫反应产物在三叉神经尾侧亚核和脊髓内的分布基本一致。致密的免疫反应产物分布于Ⅱ内层（ｉｎｎｅｒｐａｒｔ），而Ⅰ层和Ⅱ外层（ｏｕｔｅｒｐａｒｔ）染色浅淡。ＮＫ３受体阳性神经元胞体主要见于三叉神经尾侧亚核和脊髓的Ⅰ层和Ⅱ层，少量分布于脊髓后角深层。Objectives\ In order to study possible relationship between neurokinin B receptor(NK 3) and transmission and modulation of noxious sensory information, we investigated the distribution of NK 3 receptor in the caudal spinal trigeminal nucleus and spinal cord of the cat. Method\ Immunohistochemical staining was used. Results\ The distribution pattern of NK 3 receptor like immunoreactivity ( LI) in the spinal cord was similar to that of the caudal spinal trigeminal nucleus. Intense NK 3 receptor LI was observed in the inner part of lamina Ⅱ of the caudal spinal trigeminal nucleus and spinal cord; Weak NK 3 receptor LI was seen in lamina Ⅰ and outer part of lamina Ⅱ. Neuronal cell bodies with NK 3 receptor LI were mainly found in laminae Ⅰ and Ⅱ of the caudal spinal trigeminal nucleus and spinal dorsal horn, and a few were distributed in the deeper layers of the spinal dorsal horn. Conclusion\ The results suggest that NK 3 receptor might be involved in the transmission and modulation of primary noxious information in the caudal spinal trigeminal nucleus and spinal cord of the cat.

关 键 词：神经激肽B受体 三叉神经 尾侧亚核 脊髓 猫 

分 类 号：R338.3[医药卫生—人体生理学]