黄连解毒汤对自发性高血压大鼠血压和炎症因子的影响  

Effects of Huanglianjiedu-Decoction on blood pressure and inflammatory factors in spontaneous hypertension rats

作　　者：张志伟[1] 岳桂华[1] 张爱珍[1] 

机构地区：[1]广西中医学院附属瑞康医院,南宁530011

出　　处：《中华中医药杂志》2011年第7期1627-1629,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：广西科学基金项目(No.桂科自0832177)~~

摘　　要：目的:观察黄连解毒汤对自发性高血压大鼠(SHR)血压和炎症因子的影响,探讨黄连解毒汤治疗高血压的机制。方法:雄性12周龄SHR 24只随机分为黄连解毒汤组、模型对照组和卡托普利组3组,治疗6周,检测治疗前后的血压变化,测定血清中超敏C-反应蛋白(hs-CRP)、6酮前列环素(6-K-PG)、NO、内皮素-1(ET-1)、血管性血友病因子(vWF)、同型半胱氨酸(Hcy)和单核细胞趋化因子(MCP-1)变化,并以同龄Wistar Kyoto(WKY)大鼠8只做空白对照组。结果:SHR血压呈进行性增高,血清中hs-CRP、ET-1、vWF、Hcy和MCP-1升高,NO和6-K-PG降低(P<0.05,P<0.01),黄连解毒汤可控制SHR血压,降低hs-CRP、ET-1、vWF、Hcy和MCP-1,增加NO和6-K-PG(P<0.05,P<0.01)。结论:黄连解毒汤可通过调节炎症因子水平,控制SHR高血压的发展。Objective： To research the variety of the inflammatory factors and blood pressure of Spontaneous Hypertension Rats（SHR） with Huanglianjiedu-Decoction,and discuss the mechanism to cure hypertension.Method： 24 12-week-age male SHR were divided into three groups-Huanglianjiedu-Decoction group,the model group and Captopril group in random,treated for 6 weeks,tested the changes of the blood pressure pre and post the treatment separately,measured the density changes of the hs-CRP,6-K-PG,ET-1,vWF,Hcy,MCP-1 by ELLSA and NO by nitrous reductase chromatometry for those rats,and compared with 8 WKY rats in the same age for blank control.Results： The blood pressure of SHR increased progressively.The hs-CRP.ET-1.vWF.Hcy and MCP-1 increased,and 6-K-PG and NO decreased in the SHRs＇ plasma.Huanglianjiedu-decoction group could control the blood pressure of the SHR,decrease the content of the hs-CRP,Hcy,ET-1,vWF and MCP-1,and increase the content of the 6-K-PG and NO.Conclusion： Using Huanglianjiedu-decoction could improve the inflammatory response and control the hypertensive in the SHR.

关 键 词：黄连解毒汤 自发性高血压大鼠 炎症 

分 类 号：R285.5[医药卫生—中药学]