放射性口腔黏膜炎的发病过程  

Pathogenesis of radiation-induced stomatitis

作　　者：杜清华[1] 王仁生[1] 

机构地区：[1]广西医科大学第一附属医院放疗科,南宁530000

出　　处：《国际肿瘤学杂志》2011年第6期465-467,共3页Journal of International Oncology

摘　　要：放射性口腔黏膜炎是头颈部肿瘤放疗过程中常见的不良反应，影响了患者的治疗和生活质量。研究表明，射线的直接作用、氧化应激、转录因子、促炎细胞因子、病原微生物均参与放射性口腔黏膜炎的发病过程，其病理过程可分为起始、上调、放大、溃疡和愈合5个阶段。了解口腔黏膜炎的发病过程及危险因素可为有针对性的防治提供依据。Radiation-induced stomatitis is a frequent side effect for head and neck cancer patients undergoing radiotherapy, which affects both the treatment and the life quality. The direct effects of radiation, oxidative stress, transcription factor, proinflammatory cytokine and pathogenic microorganism are involved in the onset of radiation-induced stomatitis. The pathologic process can be divided into five phases including initiation, up-regulation, amplification, ulceration and healing. Understanding of the pathogenesis and risk t;actors provides basis for prevention and control of radiation-induced stomatitis.

关 键 词：口炎 放射疗法 病理过程 危险因素 

分 类 号：R473.73[医药卫生—护理学]