超顺磁性PLA-PEG微球中链霉素体内释放的实验研究  

Study of superparamagnetic streptomycin sulfate PLA-PEG block polymer microspheres in vivo release

作　　者：张芸[1] 刘传康[1] 罗聪[1] 李明[1] 周恒[2] 黄华[2] 

机构地区：[1]重庆医科大学附属儿童医院骨科,重庆400014 [2]重庆医科大学药学院药剂学教研室,重庆400016

出　　处：《重庆医科大学学报》2011年第5期592-594,共3页Journal of Chongqing Medical University

基　　金：重庆市卫生局课题资助项目(编号:2009-2-246)

摘　　要：目的:研究超顺磁性链霉素PLA-PEG共聚物微球(SuperparamagneticstreptomycinsulfatePLA-PEGblockpolymermi-crospheres,spSPM)在体内药物释放的规律。方法:用化学共沉淀法制备超顺磁Fe3O4油酸钠纳米粒,用复乳化(W/O/W)溶剂挥发法制备spSPM,新西兰大白兔10只,随机分为2组,实验组为超顺磁性链霉素微球,对照组为链霉素原料药溶液;分别臀肌注射后,定时取动物外周静脉血,采用高效液相色谱法(High performance liquid chromatography,HPLC)测定链霉素血药浓度,比较2组中药物在动物体内的释放情况。结果:研究结果显示实验组和对照组在药物体内释放方面结果存在明显差异(P<0.05)。结论:spSPM在体内具有缓释性。Objective：To study in vivo release of superparamagnetic streptomycin sulfate PLA-PEG copolymer microsphere（block spSPM）.Methods：Superparamagnetic magnetic nanoparticles Fe3O4 sodium oleate were prepared with chemical deposition;spSPM was prepared with complex emulsification（W/O/W）.10 rabbits were randomly divided into spSPM experimental group and streptomycin control group.After gluteal injection respectively,animal peripheral venous blood was drawn in fixed time for the determination of the blood concentration of sulfuric acid streptomycin by using high performance liquid chromatography（HPLC）.The medicine release in the animal body was compared.Results：Findings demonstrated significant difference between the experimental group and the control group in the in vivo release of the medicine（P〈0.05）.Conclusion：Superparamagnetic streptomycin sulfate PLA-PEG block polymer microspheres show a delayed release in vivo.

关 键 词：链霉素 PLA-PEG 超顺磁性微球 高效液相色谱法 

分 类 号：R943[医药卫生—药剂学]