糖足愈疡膏对慢性糖尿病足溃疡患者终点事件的影响  

Effect of Tangzu Yuyang Ointment on the Outcome Event of Patients with Chronic Diabetic Foot Ulcers

作　　者：李树法[1] 赵建勇[2] 刘建平[3] 向菲[1] 梁愿[1] 黎姗姗[1] 张前[4] 胡艳文[5] 李显文[6] 蒋成艳 于瑞萍[8] 汪霞[9] 

机构地区：[1]贵阳市第一人民医院内分泌科,贵阳550002 [2]贵阳市第一人民医院普外科,贵阳550002 [3]北京中医药大学循证医学中心,北京100029 [4]贵阳医学院第二附属医院内分泌科,贵州凯里556000 [5]贵阳市第四人民医院内分泌科,贵阳550000 [6]遵义医学院附属医院内分泌科,贵州遵义550000 [7]遵义医院内分泌科,贵州遵义553000 [8]贵州省人民医院内分泌科,贵阳550000 [9]解放军第44医院内分泌科,贵阳550000

出　　处：《中国中西医结合杂志》2011年第6期775-779,共5页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：贵阳市科学技术局基金项目(No.2006-35-1)

摘　　要：目的评价糖足愈疡膏治疗慢性糖尿病足溃疡的有效性和安全性。方法 57例W agner′s 1~3级慢性糖尿病足溃疡患者随机分为标准外科治疗（standard wound therapy,SWT）组（对照组,29例）和SWT加糖足愈疡膏治疗组（治疗组,28例）,观察患者溃疡愈合率、改善率及不良事件发生率,共48例患者完成最后随访并进入数据分析。结果 12周时治疗组和对照组溃疡改善率分别为79.2%和41.7%（P=0.017）,24周时分别为91.7%和62.5%（P=0.036）;第4、12和24周两组间溃疡完全愈合率和不良事件发生率差异均无统计学意义;治疗组和对照组治愈时间分别为（96±56）天、（75±53）天,差异无统计学意义（P=0.271）。结论糖足愈疡膏加SWT较单纯SWT对慢性糖尿病足溃疡安全且有更好的疗效。Objective To assess the efficacy and safety of Tangzu Yuyang Ointment（TYO） for treatment of chronic diabetic foot ulcers.Methods Fifty-seven patients with chronic diabetic foot ulcers of Wagner′s ulcer grade 1 to 3 were randomly assigned to the control group（29 cases） and the treatment group（28 cases）.Patients in the control group received the standard wound therapy（SWT）,while those in the treatment group received SWT plus TYO.The ulcer healing rate,the ulcer improvement rate and the incidence of adverse events were compared between the two groups.Totally 48 patients finished the final follow-ups and entered the data analysis.Results The ulcer improvement rate was 79.2% in the TYO group and 41.7% in the SWT group（P=0.017） at the 12th week,and 91.7% vs.62.5%（P=0.036） at the 24th week.There was no statistical difference in the ulcer healing rate and the incidence of adverse events between the two groups at week 4,12,and 24,respectively.The ulcer healing time was 96±56 days in the TYO group and 75±53 days in the SWT group,showing insignificant difference（P=0.271）.Conclusion TYO plus SWT was more safe and effective than SWT alone in the treatment of chronic diabetic foot ulcers.

关 键 词：糖足愈疡膏 补充替代医学 糖尿病足溃疡 

分 类 号：R259[医药卫生—中西医结合]