急性冠脉综合征患者血浆抵抗素浓度变化的临床研究  

The clinical significance of plasma resistin levels in patients with acute coronary syndrome

作　　者：杨丽霞[1] 李劲松[1] 齐峰[1] 王先梅[1] 郭传明[1] 苗贵华[1] 李明秋[1] 

机构地区：[1]成都军区昆明总医院心血管内科,昆明650032

出　　处：《中国医师杂志》2011年第5期611-614,共4页Journal of Chinese Physician

摘　　要：目的探讨急性冠脉综合征（ACS）患者冠状动脉病变程度与血浆抵抗素（Resistin）水平的关系。方法研究共入选400例，包括对照组90例，冠心病（CHD）组310例，其中ACS亚组217例，稳定型心绞痛（SAP）亚组93例；对各组行选择性冠状动脉造影检查及外周血浆Resistin浓度检测，分析各组冠脉病变程度与血浆Resistin水平之间的关系；CHD组中85例患者接受64层螺旋CT冠状动脉成像检查评价冠状动脉粥样斑块类型并行亚组分析。结果．CHD组Resistin水平[（889．1±248．2）pg／m1]明显高于对照组[（261．64±111．9）pg／m1]（P〈0．05）；CHD组内，ACS亚组Resistin水平[（1260．04±368．0）pg／m1]明显高于SAP亚组[（518．34±128．4）pg／m1]（P〈0．05），软斑块亚组血清抵抗素水平[（1097．834±259．69）pg／m1]、纤维斑块亚组[（981．464±107．73）pc,／m1]较钙化斑块亚组[（487．924±98．52）pg／m1]血浆Resistin水平明显升高，差异有统计学意义（P〈0．05）；逐步回归分析表明血浆Resistin水平与冠脉病变Gensini评分有显著相关性。结论CHD患者（尤其是ACS患者）血浆Resistin水平明显增高，并随冠脉病变严重程度的增加而升高，提示血浆Resistin可能促进易损斑块的形成。血浆Resistin水平结合64层螺旋cT检测可初步判断冠状动脉粥样斑块的稳定性。Objective To explore the association between plasma resistin levels and acute coronary syndrome. Methods Four hundred patients were divided into coronary heart disease （CHD） group （310） and control group （90）according to the coronary Angiography （CAG）. And CHD group was divided into ACS subgroup（ n = 217 ）and SAP subgroup （ n = 93 ）according to the clinical information. 85 cases in CHD group were underwent 64-slice spiral computed tomography coronary artery imaging. The severity and extent of coronary lesions were analyzed by CAG and graded by means of Gensini coronary score system. Resistin level in plasma of all patients was determined by enzyme linked immunosorbent assay. Results Resistin levels in CHD group [ （889. 1 ± 248.2） pg/ml ] were significant higher compared with the control group[ （261.6 ± 111.9） pg/ml] （ P 〈0. 05）, and resistin levels in ACS subgroup[ （ 1260. 0 ±368.0）pg/ nil] were much higher than that in SAP subgroup[ （518. 3 ±128.4） pg/ml] （ P 〈0. 05 ）, Conclusions The resistin levels of patients with acute coronary syndrome increased significantly and might be associated with the vulnerable plaque. Resistin levels and 64 slice spiral computed tomography coronary artery imaging can be used to detect the vulnerable plaque in CHD patients.

关 键 词：急性冠状动脉综合征/病理学/代谢 抵抗素/代谢 冠状血管/病理学 

分 类 号：R541.4[医药卫生—心血管疾病]