Association of SUMO4 Met55Val Variation with Increased Insulin Resistance in Newly Diagnosed Type 2 Diabetes in a Chinese Population  

作　　者：季振中 代喆 黄艳 Hedson Alves Martins 徐焱成 

机构地区：[1]Department of Endocrinology,Zhongnan Hospital of Wuhan University

出　　处：《Journal of Huazhong University of Science and Technology(Medical Sciences)》2011年第3期306-311,共6页华中科技大学学报（医学英德文版）

基　　金：supported by a grant from the National Natural Sciences Foundation of China (No. 30871188);the Na-tional Natural Sciences Foundation of Hubei Province (No. 303131486)

摘　　要：SUMO4 Met55Val variation was shown to be related to type 2 diabetes susceptibility and the vascular complications in Asian people.To further examine the related mechanisms,this study was designed to evaluate the association of SUMO4 Met55Val polymorphism with insulin resistance and β cell function in newly diagnosed type 2 diabetic patients in a Chinese population.Four hundred and twenty seven newly diagnosed type 2 diabetic patients were selected for SUMO4 Met55Val polymorphism genotype analysis.All subjects underwent a 75-g oral glucose tolerance test（OGTT） to estimate the insulin sensitivity and β cell function.Anthropometrics and a metabolic profile were used for phenotyping analysis.The results showed that the SUMO4 Met55Val polymorphism was associated with higher insulin resistance（P0.001） and lower insulin sensitivity（P0.001）.Patients with GG genotype had higher levels of plasma glucose,insulin and C peptide.Insulin sensitivity index（ISI） was closely correlated with body mass index（BMI） in patients with GG genotype in comparison to the counterparts with AG or AA genotype（r=-0.504 vs.r=-0.430 vs.r=-0.340）.Multiple regression linear analysis showed that SUMO4 Met55Val polymorphism was an independent determinant for insulin sensitivity（P=0.001）,which,along with triglyceride,BMI and sex,could account for 20.1% of the variation in ISI.The result remained the same after adjusting for BMI and sex.No association was found between SUMO4 Met55Val polymorphism and β cell function（all P0.05）.It was concluded that SUMO4 Met55Val variant was associated with increased insulin resistance in Chinese patients with newly diagnosed type 2 diabetes.SUMO4 Met55Val variation was shown to be related to type 2 diabetes susceptibility and the vascular complications in Asian people.To further examine the related mechanisms,this study was designed to evaluate the association of SUMO4 Met55Val polymorphism with insulin resistance and β cell function in newly diagnosed type 2 diabetic patients in a Chinese population.Four hundred and twenty seven newly diagnosed type 2 diabetic patients were selected for SUMO4 Met55Val polymorphism genotype analysis.All subjects underwent a 75-g oral glucose tolerance test（OGTT） to estimate the insulin sensitivity and β cell function.Anthropometrics and a metabolic profile were used for phenotyping analysis.The results showed that the SUMO4 Met55Val polymorphism was associated with higher insulin resistance（P0.001） and lower insulin sensitivity（P0.001）.Patients with GG genotype had higher levels of plasma glucose,insulin and C peptide.Insulin sensitivity index（ISI） was closely correlated with body mass index（BMI） in patients with GG genotype in comparison to the counterparts with AG or AA genotype（r=-0.504 vs.r=-0.430 vs.r=-0.340）.Multiple regression linear analysis showed that SUMO4 Met55Val polymorphism was an independent determinant for insulin sensitivity（P=0.001）,which,along with triglyceride,BMI and sex,could account for 20.1% of the variation in ISI.The result remained the same after adjusting for BMI and sex.No association was found between SUMO4 Met55Val polymorphism and β cell function（all P0.05）.It was concluded that SUMO4 Met55Val variant was associated with increased insulin resistance in Chinese patients with newly diagnosed type 2 diabetes.

关 键 词：SUMO4 type 2 diabetes insulin resistance 

分 类 号：R587.1[医药卫生—内分泌]