TPC1 - SV Channels Gain Shape  

作　　者：Rainer Hedrich Irene Marten 

机构地区：[1]University Wuerzburg, Institute for Molecular Plant Physiology and Biophysics, Julius-von-Sachs Platz 2, D-97082 Wuerzburg, Germany [2]King Saud University, Zoology Department, College of Science, RO. Box 2455, Riyadh 11451, Saudi Arabia

出　　处：《Molecular Plant》2011年第3期428-441,共14页分子植物（英文版）

摘　　要：The most prominent ion channel localized in plant vacuoles is the slow activating SV type. Slow vacuolar （SV） channels were discovered by patch clamp studies as early as 1986. In the following two decades, numerous studies revealed that these calcium- and voltage-activated, nonselective cation channels are expressed in the vacuoles of all plants and every plant tissue. The voltage-dependent properties of the SV channel are susceptible to modulation by calcium, pH, redox state, as well as regulatory proteins. In Arabidopsis, the SV channel is encoded by the AtTPC1 gene, and even though its gene product represents the by far largest conductance of the vacuolar membrane, tpcl-loss-of-function mutants appeared not to be impaired in major physiological functions such as growth, development, and reproduction. In contrast, the fou2 gain-of-function point mutation D454N within TPC1 leads to a pronounced growth phenotype and increased synthesis of the stress hormone jasmonate. Since the TPC1 gene is present in all land plants, it likely encodes a very general function. In this review, we will discuss major SV channel properties and their impact on plant cell physiology.The most prominent ion channel localized in plant vacuoles is the slow activating SV type. Slow vacuolar （SV） channels were discovered by patch clamp studies as early as 1986. In the following two decades, numerous studies revealed that these calcium- and voltage-activated, nonselective cation channels are expressed in the vacuoles of all plants and every plant tissue. The voltage-dependent properties of the SV channel are susceptible to modulation by calcium, pH, redox state, as well as regulatory proteins. In Arabidopsis, the SV channel is encoded by the AtTPC1 gene, and even though its gene product represents the by far largest conductance of the vacuolar membrane, tpcl-loss-of-function mutants appeared not to be impaired in major physiological functions such as growth, development, and reproduction. In contrast, the fou2 gain-of-function point mutation D454N within TPC1 leads to a pronounced growth phenotype and increased synthesis of the stress hormone jasmonate. Since the TPC1 gene is present in all land plants, it likely encodes a very general function. In this review, we will discuss major SV channel properties and their impact on plant cell physiology.

关 键 词：SV channel TPC1 vacuole transport CICR. 

分 类 号：Q73[生物学—分子生物学] TN253[电子电信—物理电子学]