Expression and function of aquaporins in peripheral nervous system  

作　　者：Tong-hui MA Hong-wen GAO Xue-dong FANG Hong YANG 

机构地区：[1]Central Research Laboratory, Jilin University Bethune Second Hospital, Changchun 130041, China [2]School of Life Sciences, Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery, Liaoning Normal University, Dalian 116029, China

出　　处：《Acta Pharmacologica Sinica》2011年第6期711-715,共5页中国药理学报（英文版）

基　　金：This work was supported by National Natural Science Foundation （No 30670477）, Dalian Municipal Science and Technology Fund （2008E11SF162）, and National Basic Research Program of China （＂973＂ Program, No 2009CB521908）.

摘　　要：The expression and role of the aquaporin （AQP） family water channels in the peripheral nervous system was less investigated. Since 2004, however, significant progress has been made in the immunolocalization, regulation and function of AQPs in the peripheral nervous system. These studies showed selective localization of three AQPs （AQP1, AQP2, and AQP4） in dorsal root ganglion neurons, enteric neurons and glial cells, periodontal Ruffini endings, trigeminal ganglion neurons and vomeronasal sensory neurons. Functional characterization in transgenic knockout mouse model revealed important role of AQP1 in pain perception. This review will summarize the progress in this field and discuss possible involvement of AQPs in peripheral neuropathies and their potential as novel drug targets.The expression and role of the aquaporin （AQP） family water channels in the peripheral nervous system was less investigated. Since 2004, however, significant progress has been made in the immunolocalization, regulation and function of AQPs in the peripheral nervous system. These studies showed selective localization of three AQPs （AQP1, AQP2, and AQP4） in dorsal root ganglion neurons, enteric neurons and glial cells, periodontal Ruffini endings, trigeminal ganglion neurons and vomeronasal sensory neurons. Functional characterization in transgenic knockout mouse model revealed important role of AQP1 in pain perception. This review will summarize the progress in this field and discuss possible involvement of AQPs in peripheral neuropathies and their potential as novel drug targets.

关 键 词：AQUAPORINS peripheral nervous system neuronal transduction gene knockout gene expression PAIN 

分 类 号：Q51[生物学—生物化学] Q42