窦房结细胞自律性与超极化激活起搏电流关系的研究进展  

Research Progress in Relation between Automaticity of Sinoatrial Node Cells and Funny Current

作　　者：汪艳丽[1] 刘如秀[1] 

机构地区：[1]中国中医科学院广安门医院心内科,北京100053

出　　处：《医学综述》2011年第12期1778-1780,共3页Medical Recapitulate

基　　金：国家自然科学基金(30873332);北京市自然科学基金(7102135)

摘　　要：窦房结是正常心脏活动的起搏点,在心脏传导系统中自律性最高,窦房结细胞的自动除极是其自律性产生的基础,多种离子通道及相应电流参与窦房结细胞自律性活动,其中超极化激活环核苷酸门控通道（HCN）及其电流（If）在窦房结细胞自律性产生过程中起着重要作用,HCN通道共有HCN1~4四个亚型,在心脏窦房结细胞中HCN4是主要的亚型,负责形成If,HCN4及相关If对窦房结自律性有着重要的影响。Sinoatrial node（SAN）is the primary cardiac pacemaker with the highest automaticity in the conducting system of heart.The automatic depolarization of sinoatrial node cells is the basis of its automaticity.Many different membrane ionic channels and their currents coordinately take part in the automatic activity,in which the hyper-polarization-activated cyclic nucleotide-gated cation channel（HCN）and its funny current（If）play an important role.There are four isoforms in HCN family,and HCN4 is the most important one which forms the If.HCN4 and relative If have important influence on sinoatrial node cells′ atomatic.

关 键 词：窦房结细胞 离子通道 超极化激活起搏电流 

分 类 号：R33[医药卫生—人体生理学]