2008—2010年北京市西城区志贺菌血清型变迁及耐药性分析  

Analysis on Change of Serum Types and Drug Resistance of Shigella in Xicheng District of Beijing from 2008 to 2010

作　　者：刘静[1] 苗元[1] 王丽萍[1] 崔京辉[1] 王永全[1] 吉彦莉[1] 

机构地区：[1]北京市西城区疾病预防控制中心微生物检验科,100120

出　　处：《职业与健康》2011年第12期1377-1379,共3页Occupation and Health

摘　　要：目的 2008—2010年北京市西城区志贺菌血清型变迁及耐药性分析。方法按《全国细菌性痢疾监测方案》的要求进行。结果 2008年西城区福氏志贺菌7株,占63.6%;宋内志贺菌4株,占36.4%。2009年西城区福氏志贺菌12株,占37.5%;宋内志贺菌19株,占59.4%;鲍氏志贺菌1株,占3.1%。2010年福氏志贺菌6株,占14.3%;宋内志贺菌36株,占85.7%。药敏试验结果:志贺菌对头孢吡肟、头孢西丁、头孢他啶、氧氟沙星、左氧氟沙星、诺氟沙星、氨曲南药物敏感。对氨苄西林、磺胺、奈啶酸耐药。结论 2008—2010年北京市西城区志贺菌血清型主要为福氏志贺菌和宋内志贺菌,但是福氏志贺菌已呈逐年减少趋势,而宋内志贺菌呈逐年增多趋势。志贺菌对头孢类药物和氟喹诺酮类药物敏感,临床宜选用此类药品进行治疗。[Objective]To analyze the change of serum types and drug resistance of Shigella in Xicheng district of Beijing from 2008 to 2010.[Methods]The study was conducted according to the National protocol of shigellosis surveillance.[Results]In 2008,there were 7 strains of Shigella flexneri and 4 strains of Shigella sonnei in Xicheng district,which accounted for 63.6% and 36.4% respectively.In 2009,there were 12 strains of Shigella flexneri,19 strains of Shigella sonnei and 1 strain of Shigella boydii,which accounted for 37.5%,59.4% and 3.1% respectively.In 2010,there were 6 strains of Shigella flexneri and 36 strains of Shigella sonnei,which accounted for 14.3% and 85.7% respectively.The results of drug sensitivity test showed that Shigella was sensitive to cefepime,cefoxitin,ceftazidime,ofloxacin,levofloxacin,norfloxacin and aztreonam,and it was resistant to ampicillin,sulfanilamide and nalidixie acid.[Conclusion]From 2008 to 2010,the main serum types of Shigella in Xicheng district of Beijing are Shigella flexneri and Shigella sonnei,while the former decreased and the latter increased year by year.Shigella is sensitive to cephalosporin and fluoroquinolones which are suggested for the clinical treatments.

关 键 词：志贺菌 血清型 耐药性分析 

分 类 号：R181.3[医药卫生—流行病学]