美沙酮门诊治疗人员617例感染HIV和HCV分析  

Analysis on 617 Cases of HIV and HCV Infection among Patients in Methadone Maintenance Treatment Clinics

作　　者：幸小弘[1] 王志成[2] 彭孝武[2] 

机构地区：[1]湖北省荆州市中心医院传染科,434000 [2]荆州市疾病预防控制中心

出　　处：《职业与健康》2011年第12期1381-1383,共3页Occupation and Health

摘　　要：目的了解荆州市美沙酮门诊吸毒人员HIV、HCV的感染状况及其影响因素。方法对吸毒人员吸毒行为、肝功能有无异常、营养情况、并发症等进行问卷调查,并采血样检测HIV抗体、HCV抗体。结果 617名吸毒者中,HIV、HCV感染率分别为2.1%和70.5%。HCV感染与吸毒年限有关。男女吸毒人员吸毒行为比较:初吸毒年龄和吸毒年限差异有统计学意义(均P<0.01和P<0.05),但平均吸毒频次、平均吸毒量差异无统计学意义(均P>0.05)。女性吸毒人员中有并发症的比例(21.43%)高于男性吸毒人员中有并发症的比例(12.83%),差异有统计学意义(P<0.01)。营养状况不同吸毒人员的HCV感染无统计学差异(P>0.05),但营养状况不同吸毒人员肝功能和并发症的发生率差异有统计学意义(P<0.01)。用多因素logistic分析吸毒人员感染HCV的主要影响因素,其顺序为初吸年龄、吸毒量、肝功能、并发症、年龄。其中初吸年龄与HCV感染呈负相关。结论对吸毒人群中的高危行为应采取干预措施并在该人群中开展艾滋病知识的宣传教育工作。[Objective]To study the status of HIV and HCV infection among drug addicts in methadone maintenance treatment clinics and its influencing factors in Jingzhou city.[Methods]The questionnaire survey for drug use behavior,liver function,nutritional status and complication was conducted among drug addicts,and blood samples were collected to test HIV antibody and HCV antibody.[Results]Among 617 drug addicts,the infection rate of HIV and HCV was 2.1% and 70.5% respectively,and the HCV infection was related to the drug addiction years.There were significant differences in age of first drug use and drug addiction years between male and female drug addicts（P〈0.01 and P〈0.05）,but the differences in average frequency of drug use and average amount of drug use between male and female drug addicts were not significant（P〈0.05 all）.The incidence of complications in female drug addicts（21.43%） was higher than that in male（12.83%） significantly（P〈0.01）.There was no significant difference in infection rate of HCV among drug addicts with different nutritional status（P〈0.05）,but differences in the incidence of abnormal liver function and complications among drug addicts with different nutritional status were significant（P〈0.01）.The multiple logistic regression analysis showed that the main influencing factors of HCV infection were age of first drug use,amount of drug use,liver function,complications and age,and age of first drug use had a negative correlation with HCV infection.[Conclusion]The intervention measures for high-risk behavior should be adopted among drug addicts,and education of knowledge about AIDS should be carried out on this population.

关 键 词：美沙酮门诊 吸毒人员 HIV HCV 相关因素 

分 类 号：R181.3[医药卫生—流行病学]