强直性脊柱炎和类风湿关节炎患者低相对分子质量IgM水平的研究  

Low molecule weight lgM in ankylosing spondylitis and rheumatoid arthritis

作　　者：张璐定[1] 张立斌[1] 陆慧琦 吴歆[1] 周凌[1] 杨晓平[1] 徐沪济[1] 

机构地区：[1]第二军医大学附属长征医院风湿免疫科,上海200003 [2]临床诊断科

出　　处：《中华风湿病学杂志》2011年第6期404-406,共3页Chinese Journal of Rheumatology

基　　金：上海市卫生局基金（054101）

摘　　要：目的研究强直性脊柱炎（AS）和类风湿关节炎（RA）患者体内低相对分子质量IgM水平的变化。方法取AS、RA患者和健康对照人群血清，超滤法分离低相对分子质量IgM，酶联免疫吸附试验测定低相对分子质量IgM比例。采用Mann～WhitneyU检验方法进行统计分析。结果As和RA患者血清低相对分子质量IgM比例较健康对照明显升高（分别为0．194±0123，0．061±0．026，0．028±0．165）；低相对分子质量IgM比例与患者病情活动度无明显相关。结论低相对分子质量lgM升高可能是As和RA患者体内体液免疫功能紊乱的表现，但其具体的病理意义尚需进一步研究。Objective To study the serum levels of low molecule weight IgM （LMW IgM） in ankylosing spondylitis （AS） patients and rheumatoid arthritis （RA） patients and to evaluate the relationship of LMW IgM levels with the disease activities. Methods The levels of LMW IgM and pentamerie IgM in AS patients, RA patients and healthy controls were measured with ELISA after separated using uhrafiltration assay. Differences in the percentage of LMW IgM between subject groups were analysed using Mann-Whitney U test. Results The percentages of LMW IgM increased dramatically in AS patients and RA patients compared with healthy controls （0.194±0123, 0.061 ±0.026, 0.028±0.165 separately）. The LMW IgM percentages were not correlated with the disease activities. Conclusion The increase of LMW IgM indicates humoral immune function abnormality in AS patients and RA. However, the mechanism needs further study.

关 键 词：免疫球蛋白M 脊柱炎 强直性 关节炎 类风湿 

分 类 号：R593.22[医药卫生—内科学]