分子探针在细胞凋亡检测中的研究进展  

Progress in Molecular Probe for the Detection of Apoptosis

作　　者：唐敏[1,2] 曾文彬[3,2] 曹亚[1,2] 

机构地区：[1]中南大学肿瘤研究所,长沙410078 [2]中南大学分子影像研究中心,长沙410078 [3]中南大学药学院,长沙410013

出　　处：《中国生物工程杂志》2011年第6期124-128,共5页China Biotechnology

摘　　要：分子探针应用于细胞凋亡检测具有直观、无创伤和实时动态观察凋亡分子信息的特点,在疾病早期诊断、监测疾病发展进程、评估疾病治疗效果、发展新的治疗方案等方面具有较好的应用前景。综述了近年来靶向细胞凋亡探针的设计、作用机制、应用等相关的研究进展,并根据亲和组件的作用机制对分子探针进行分类介绍。The detection and quantification of apoptosis with molecular probes would be desirable to provide clinicians with intuitive, noninvasive and real-time dynamic information, assisting in diagnosing early diseases, monitoring the course of disease, assessing the efficacy of disease treatment and developing new therapeutic strategies. According to related literatures in the past decade, The progresses in mechanism of molecular probes and application in the related research areas were probes are classified based on the mechanism of affinity components. the fields of summarized. probes design, The molecular

关 键 词：分子影像 分子探针 细胞凋亡 

分 类 号：R445[医药卫生—影像医学与核医学] R363[医药卫生—诊断学]