^(13)N-NH_3 PET/CT心肌灌注显像评价葱白提取物对猪缺血再灌注的影响  

Effects of Extract of Bulbus Allii Caespitosi on Cardiocyte Viability of Swine With Myocardial Reperfusion Injury Evaluated by ^(13)N-NH_3 Positron Emission Tomography/Computed Tomography

作　　者：郝建军[1] 朱旭[1] 张介眉[2] 柯于鹤[1] 朱浩[1] 凃新[3] 夏豪[4] 吴志坚[5] 王腾[4] 吴斌[6] 

机构地区：[1]湖北中医药大学,武汉430065 [2]武汉市中西医结合医院 [3]华中科技大学生命科学与技术学院 [4]武汉大学人民医院 [5]华中科技大学同济医学院附属协和医院 [6]湖北省中医院

出　　处：《内科急危重症杂志》2011年第3期168-170,共3页Journal of Critical Care In Internal Medicine

基　　金：国家自然科学基金项目(No:30772879)

摘　　要：目的:采用13N-NH3 PET/CT正电子发射体层扫描技术评价葱白提取物对猪缺血再灌注心肌血流灌注的影响。方法:将24只DIV系猪随机分为假手术组、空白模型组、曲美他嗪组和葱白提取物组,每组6只。通过球囊封堵冠状动脉制备缺血再灌注模型,造模后第4天,葱白提取物组用葱白提取物灌胃(5.93mg/kg,2次/d),曲美他嗪组灌胃曲美他嗪(20mg/kg,2次/d),其他2组给同体积生理盐水,连续给药28d。各组于最后1次给药后1h行13N-NH3心肌显像检测,采用4分法评价相应节段心肌血流灌注。结果:葱白提取物与曲美他嗪均可改善缺血再灌注心肌血流灌注而保护心肌细胞,与空白模型组比较,差异有统计学意义(P<0.01);葱白提取物组与曲美他嗪组比较,差异无统计学意义(P>0.05)。结论:葱白提取物可以改善猪缺血再灌注心肌血流灌注。Objective：To investigate the effects of extract of Bulbus Allii Caespitosi on cardiocyte viability of swine with myocardial reperfusion injury by analyzing 13N-NH3 position emission tomography（PET）imaging.Methods：Twenty-four swine were randomly divided into sham-operated group,untreated group,trimetazidine group and extract of Bulbus Allii Caespitosi group（each n=6）.Myocardial reperfusion injury was induced by plugging the anterior descending coronary artery of swine with sacculus.Bulbus Allii Caespitosi（5.93 mg/kg） or trimetazidine（20 mg/kg） was given twice daily for 28 days.Then myocardial reperfusion imaging was detected with 13N-NH3 one hour after the last medication,and myocardial perfusion of relative sections were evaluated by the method of four points corresponding evaluation.Results：Compared with the untreated group,Bulbus Allii Caespitosi and trimetazidine could improve the activity of myocardial cells after myocardial infarction（P 0.01）,and there were no significant differences between Bulbus AIlii Caespitosi group and trimetazidine group（P0.05）.Conclusion：Bulbus Allii Caespitosi can improve myocardial ischemia in swine.

关 键 词：心肌缺血再灌注 心肌细胞活力 13N-NH3 PET/CT 葱白提取物 曲美他嗪 猪 

分 类 号：R256.22[医药卫生—中医内科学]