CTX/淀粉接枝PLA共聚物微球的制备及药物释放行为  

Preparation and release of CTX microspheres encapsulated in starch graft PLA

作　　者：杨小玲[1] 

机构地区：[1]咸阳师范学院化学与化工学院,陕西咸阳712000

出　　处：《应用化工》2011年第6期964-968,共5页Applied Chemical Industry

基　　金：陕西省自然科学基金项目(08JK482)

摘　　要：采用乳化-溶剂挥发法,以头孢噻肟钠(CTX)为模型药物,以自制两亲性聚合物淀粉聚乳酸接枝共聚物(ST-g-PLA)为药物载体,制备了CTX/ST-g-PLA载药微球。考察了乳化剂PVA浓度、油水体积比、ST-g-PLA浓度及搅拌速度对微球粒径、载药量及包裹率的影响,采用IR,DSC和SEM等技术对微球结构进行了表征,研究了微球在4种不同介质中的降解性及体外释药性能。结果表明,当PVA浓度为2%,Vo/Vw=1∶6,共聚物浓度为30%时,制备的微球外型规则,分散性好,载药率为8.2%,包载率为49.2%;微球在不同环境中降解速率不同:肠液>碱液>PBS>酸液;较PLA微球,CTX/ST-g-PLA微球有良好的缓释性。Microspheres containing drug were prepared by oil-in-water emulsification-solvent evaporation technique,with the self-made amphiphilic and biodegradable polymer,starch graft poly（lactic acid）（ST-g-PLA） as the carrier,and cefotaxime as the model drug.The effect of PVA,oil/water vacuum ratio（Vo/Vw）,polymer concentration in organic solvent,and stirring speed on diameter of microsphere,drug loading and ecapsulation efficiency were discussed.The microspheres were characterized by IR,DSC and SEM.The degradation ability of the microspheres in four surroundings was examined,and the drug release in vitro was evaluated.The results showed that when concentration of PVA and ST-g-PLA were 2% and 30%,respectively,Vo/Vw was 1∶6,the prepared microspheres had spherical shape with uniformity size and good dispersion.The drug loading rate and encapsulation efficiency were 8.2% and 49.2%,respectively.The degradation rate of microspheres were： artificial intestinal liquidalkali liquidPBSacid liquid,and the sustained release was remarkable.

关 键 词：淀粉/聚乳酸共聚物 头孢噻肟钠 微球 降解性 缓释性 

分 类 号：TQ316.6[化学工程—高聚物工业]