珂立苏联合鼻塞式持续气道正压通气治疗重症胎粪吸入综合征的临床观察  

Clinical observation on severe meconium aspiration treated with pulmonary surfactant combined with NCPAP

作　　者：范跃[1] 黄良富[1] 严虎[2] 

机构地区：[1]安徽省马鞍山市人民医院儿科,243000 [2]上海市第一妇婴保健院新生儿科

出　　处：《中国妇幼保健》2011年第18期2847-2849,共3页Maternal and Child Health Care of China

摘　　要：目的:探讨肺泡表面活性物质(珂立苏)联合鼻塞式持续气道正压通气(NCPAP)治疗重症胎粪吸入综合征的临床疗效。方法:将58例胎粪吸入综合征患儿随机分成两组。治疗组28例,采用NCPAP及常规治疗的同时气道注入珂立苏;观察组30例,给予NCPAP及常规治疗。观察两组患儿血气数值、氧合功能,NCPAP参数和临床疗效。结果:治疗后的不同时期,治疗组患儿的PO2和氧合指数明显高于对照组,PCO2明显低于对照组,差异有统计学意义;治疗组NCPAP参数PEEP和FiO2能及早下调,上机时间、用氧时间及改机械通气病例数均显著少于对照组。结论:珂立苏联合NCPAP治疗重症胎粪吸入综合征疗效显著、方法简单、安全性好,值得临床推广应用。Objective：To explore the clinical efficacy of pulmonary surfactant（PS） combined with nasal continuous positive airway pressure（NCPAP） in treatment of severe meconium aspiration syndrome（MAS）.Methods：58 children with MAS were divided into two groups randomly：28 children in treatment group were treated with NCPAP,conventional treatment and airway application of PS;30 children in observation group were treated with NCPAP and conventional treatment.The indexes of the blood gas,oxygenation functions,NCPAP parameters and clinical efficacies in the two groups were observed.Results：At different periods after treatment,PO2 and oxygenation index in treatment group were significantly higher than those in control group,while PCO2 in treatment group were significantly lower than that in control group;NCPAP parameters（PEEP and FiO2） in treatment group could fall timely;the time of mechanical ventilation,oxygen time and the number of cases converting to mechanical ventilation in treatment group were significantly lower than those in control group.Conclusion：The clinical efficacy of PS combined with NCAPA is quite effective,simple and safe in treatment of severe MAS,which is worthy to be popularized.

关 键 词：肺泡表面活性物质 鼻塞持续气道正压通气 胎粪吸入综合征 

分 类 号：R722.1[医药卫生—儿科]