牛膝精对辐照小鼠造血干细胞和红系造血祖细胞的影响  

Effects of Extract of Achynanthis Bidentatae on CFU-S and Hemopoiesis of BFU-E、CFU-E in Irradiated Mice

作　　者：全宏勋 张宇明[2] 马素好 冯向功 邓爱民 张海林 

机构地区：[1]郑州澍青医学高等专科学校,河南郑州450064 [2]河南职工医学院

出　　处：《中国辐射卫生》2011年第2期144-145,共2页Chinese Journal of Radiological Health

摘　　要：目的探讨牛膝精(ABE)对辐照小鼠造血干细胞(以CFU-S表示)和早期红系造血祖细胞[以红系爆式集落形成单位(BFU-E)表示]和晚期红系造血祖细胞[以晚期红系集落形成单位(CFU-E)表示]的影响。方法采用脾集落形成和造血祖细胞培养技术,观察了牛膝精对辐照小鼠脾重、造血干细胞、早期红系造血祖细胞和晚期红系造血祖细胞的影响。结果该药能使受照鼠脾重及脾集落数明显提高,但不能刺激早、晚期红系造血祖细胞的活性。结论牛膝精能刺激造血干细胞的增殖,但对其向红系分化无明显影响。Objective To study the Extract of Achynanthis Bidentatae（ABE） on colony forming unit-spleen（CFU-S）and hemopoiesis of burst forming unit-erythroid（BFU-E）、colony forming unit-erythroid（CFU-E） in Irradiated mice.Methods Using techniques of CFU-S and cell culture of hemopoietic progenitors in vitro,the authors observed the effects of ABE on weight of spleen﹑CFU-S﹑BFU-E and CFU-E.Results It is shown the weight of spleen and the number of CFU-S was increased,but there was no stimulation activity on BFU-E and CFU-E.Conclution ABE may stimulate the proliferation of CFU-S,but there was no effect on differentiation of BFU-E and CFU-E.

关 键 词：牛膝精 造血干细胞 早期红系造血祖细胞 晚期红系造血祖细胞 辐照小鼠 

分 类 号：R811.5[医药卫生—放射医学]