丝胶/海藻酸钠复合凝胶粒的制备及其结构性能表征  

Preparation and Characterization of Composite Hydrogel Beads Containing Sericin and Sodium Alginate

作　　者：张海萍[1] 邓连霞[1] 王雪云[1] 闵思佳[1] 杨明英[1] 杨磊[1] 何文[1] 朱良均[1] 

机构地区：[1]浙江大学应用生物资源研究所,杭州310029

出　　处：《蚕业科学》2011年第3期456-460,共5页ACTA SERICOLOGICA SINICA

基　　金：浙江省教育厅项目(No.Y200803175)

摘　　要：为了改良丝胶型药物载体的结构性能,将丝胶粉末与海藻酸钠溶液均匀混合后,采用氯化钙胶凝法制备了粒径为1.88 mm±0.15 mm的丝胶/海藻酸钠复合凝胶粒。红外光谱检测表明该复合凝胶粒中的丝胶与海藻酸钠之间以物理方式混和;差示扫描量热分析发现丝胶与海藻酸钠复合后,其结构稳定性有所提高;机械性检测表明丝胶/海藻酸钠复合凝胶粒具有更好的力学性能;溶胀性检测表明丝胶/海藻酸钠复合凝胶粒具有pH敏感溶胀性。研究结果表明丝胶/海藻酸钠复合凝胶粒使丝胶作为药物固定化载体的结构与性能得到改善,更有利于开发利用。To improve the structural property of sericin-based drug delivery carriers,sericin powder was homogeneously mixed with sodium alginate solution and then injected into calcium chloride solution to form sericin/sodium alginate composite hydrogel beads with mean size of 1.88 mm±0.15 mm.Fourier transform infrared spectrometry（FTIR） analysis revealed that sericin was physically mixed with sodium alginate in the composite hydrogel beads.Differential scanning calorimetry（DSC） analysis showed that the composite hydrogel beads had higher structural stability than sericin itself.Mechanical property test proved that the sericin/sodium alginate composite hydrogel beads had better mechanical properties.Swelling property analysis indicated that the sericin/sodium alginate composite hydrogel beads possessed a pH value sensitive swelling property.The above results indicated that the sericin/sodium alginate composite hydrogel beads could improve structure and function of sericin as a drug immobilization carrier,being favorable to further exploitation for practical application.

关 键 词：丝胶 海藻酸钠 凝胶粒 稳定性 力学性能 溶胀性 

分 类 号：R318.08[医药卫生—生物医学工程]