无催化剂条件下微波辐射一步法合成2-氨基-4-芳基-5-氧代-5,6,7,8-四氢-4H-苯并吡喃-3-腈  

One-Pot Synthesis of 2-Amino-4-aryl-5-oxo-5,6,7,8-tetrahydro-4H-benzopyran-3-carbonitrile under Microwave Irradiation without Catalyst

作　　者：栾长军[1] 王建强[1] 张国华[1] 王伟[1] 唐拾贵[2] 郭成[1] 

机构地区：[1]南京工业大学理学院,南京210009 [2]南京工业大学生物与制药工程学院,南京210009

出　　处：《有机化学》2011年第6期860-864,共5页Chinese Journal of Organic Chemistry

摘　　要：以芳醛、丙二腈、1,3-环己二酮为原料在无催化剂条件下,分别用微波辐射和传统加热法合成了一系列2-氨基-4-芳基-5-氧代-5,6,7,8-四氢-4H-苯并吡喃-3-腈(4a～4g)衍生物.与常规加热方法相比,微波辐射法具有反应时间短、产率高、后处理方便、环境友好等优点,所有化合物均经IR,1H NMR和元素分析确定.A series of 2-amino-4-aryl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile derivatives（4a-4g） were prepared by using 1,3-cyclohexanedione,aromatic aldehydes and malononitrile in anhydrous alcohol under microwave irradiation without catalyst.Compared with conventional heating method,the method of microwave irradiation possesses advantages including short time,high yield and environmental friendliness,etc.The structures of these compounds were characterized by IR,1H NMR spectra and elemen-tal analysis.

关 键 词：芳醛 丙二腈 1 3-环己二酮 苯并吡喃 微波 

分 类 号：TQ463.5[化学工程—制药化工]