CYP2J2＊7与中国汉族人冠心病相关性研究  

The correlation between the CYP2J2＊ 7 gene polymorphism and coronary heart disease in Chinese Han population

作　　者：詹同运[1] 石磊[2] 赵树进[2] 邱健[3] 贺宝霞[2] 李锐[3] 

机构地区：[1]华南理工大学生物科学与工程学院,广州510006 [2]广州军区广州总医院药剂科,广州510010 [3]广州军区广州总医院心内科,广州510010

出　　处：《广东医学》2011年第12期1543-1545,共3页Guangdong Medical Journal

基　　金：广东省科技计划项目(编号:2009B080701105)

摘　　要：目的研究CYP2J2*7(即G-50T)与中国汉族人冠心病的相关性。方法采用聚合酶链反应-限制性内切酶片段长度多态性(PCR-RFLP)法对703例(347例冠心病患者+356例对照者)无血缘关系的研究对象进行基因分型并随机抽取部分样本采用直接测序的方法验证基因型。结果 (1)GT/TT基因型在冠心病组和对照组的分布频率分别为9.51%和5.07%,两组比较差异有统计学意义(P=0.02,OR=1.88,95%CI:1.08～3.27);(2)GT/TT基因型在男性冠心病病例与男性对照组中的分布频率差异无统计学意义(P=0.18),在女性冠心病病例与女性对照组中的分布频率差异有统计学意义(P=0.04)。结论 CYP2J2*7突变与中国汉族人冠心病的发生具有相关性,这种相关性主要表现在女性人群中。Objective To evaluate the correlation between the polymorphism of CYP2J2 ＊7 and coronary heart disease （CHD） in Chinese Han population. Methods The genotype was analyzed with polymerase chain reaction -restriction fragment length polymorphlism （ PCR - RFLP） in CHD group （ n = 347 ） and control group （ n = 355 ）. Direct sequencing was applied in random samples for genotype confirmation. Results （ 1 ） The frequencies of GT/TT were 9.51% and 5.07% in CHD group and control group, respectively, with significant difference in distribution （ P = 0. 02, OR = 1.88, 95% CI： 1.08 -3. 27）. （2） Although no significant difference was revealed in GT/TT distribution in male popula- tion between the two groups （ P = 0. 18 ） , significant difference was revealed in females （ P = 0.04）. Conelusion There is significant correlation between CYP2J2 ＊7 and CHD in the Chinese Han female population.

关 键 词：细胞色素P450CYP2J2 单核苷酸多态性 冠心病 环氧化二十碳三烯酸 

分 类 号：R541.4[医药卫生—心血管疾病]