血栓性微血管病9例临床分析  

Clinical analysis of nine patients with thrombotic microangiopathy

作　　者：张旗[1] 薛祖光[1] 杨言[1] 李伟平[1] 陈雪瑜[1] 闫金松[1] 

机构地区：[1]大连医科大学附属第二医院血液科,辽宁大连116027

出　　处：《大连医科大学学报》2011年第3期248-252,共5页Journal of Dalian Medical University

摘　　要：[目的]了解血栓性微血管病(Thrombotic microangiopathy,TMA)的临床特征及治疗,结合文献探讨其发病机制以加深对该病的认识。[方法]对9例TMA患者的临床表现特点、治疗及预后进行回顾性分析。[结果]患者主要临床表现为微血管病性贫血(9/9),血小板减少(9/9),乳酸脱氢酶升高(9/9),不同程度的肾脏损害和中枢神经系统症状(9/9),发热(5/9);6例治愈,3例死亡。[结论]TMA起病急、进展快、死亡率高、预后差,应提高对本病的认识,早诊断、早治疗、减少死亡率。[Objective] To study the clinical characteristics and treatment of thrombotic microangiopathy（TMA） for improve recognition of TMA,combined with reviewing literatures.[Methods] Clinical data including manifestation,treatment and prognoses of 9 patients with TMA admitted to our hospital between January 2007 and December 2010 were analyzed retrospectively.[Results] The clinical manifestation was characterized by microangiopathic hemolytic anemia（9/9）,thrombocytopenia（9/9）,elevated serum LDH value（9/9）,renal damage and neurological abnormalitics（9/9） and fever（5/9）.Six of the patients were cured and 3 of them died.[Conclusion] TMA is a kind of severe acute syndrome with high mortality and bad prognosis.We should improve recognition of TMA for quick diagnosis and treatment in order to obtain better efficacy and less mortality.

关 键 词：血栓性微血管病 临床分析 发病机制 

分 类 号：R554.6[医药卫生—血液循环系统疾病]