正交设计优化三氧化二砷纳米粒的制备工艺  

Preparation of arsenic trioxide nanoparticles by orthogonal design

作　　者：杨国夫[1] 王文波[1] 

机构地区：[1]哈尔滨医科大学附属第一医院骨科,黑龙江哈尔滨150001

出　　处：《哈尔滨医科大学学报》2011年第2期131-134,共4页Journal of Harbin Medical University

基　　金：黑龙江省科学技术攻关资助项目(GC08C421)

摘　　要：目的制备三氧化二砷纳米粒,并通过正交实验对其处方因素进行优化。方法以聚乳酸/羟基乙酸共聚物[Poly(lactic-co-glycolic acid),PLGA]为载体材料,利用溶剂转移法制备三氧化二砷纳米粒,将粒径分布、载药量、包封率作为优化指标,通过正交实验优化处方,得到制备三氧化二砷纳米粒的条件和工艺。结果所制备的纳米粒形态良好,平均粒径为223.2 nm,载药量为21.5%,包封率87.4%。结论该优化工艺重现性好,载药量和包封率较高,适用于三氧化二砷纳米粒的制备。Objective To prepare and optimize the formulation of arsenic trioxide nanoparticles（ATO-NPs）.Methods ATO-NPs was prepared by [Poly（lactic-co-glycolic acid）,PLGA] with solvent displacement method.Optimal preparation conditions were selected with orthogonal design.Mean diameter and size distribution of nanoparticles,drug loading and entrapment efficiency were used as evalualating indicators.Results The ATO-NPs produced by the selected procedure were good in shape,and the mean diameter was 223.2 nm.The drug loading was about 21.5% and entrapment efficiency was 87.4%.Conclusion The ATO-NPs has a high drug loading and entrapment efficiency.Optimization of preparation techniques is stable and suitable for the ATO-NPs production.

关 键 词：三氧化二砷 聚乳酸-羟基乙酸共聚物 正交设计 纳米粒 

分 类 号：R979.19[医药卫生—药品]