白细胞介素18与2型糖尿病大血管病变关系的研究  

Association between interleukin-18 and type 2 diabetes mellitus with macroangiopathy

作　　者：徐莹[1] 董霞[1] 徐同道[1] 周艳[1] 刘鹏[1] 张玉[1] 戴红双[1] 周立红[1] 

机构地区：[1]哈尔滨医科大学附属第一医院内分泌一科,黑龙江哈尔滨150001

出　　处：《哈尔滨医科大学学报》2011年第2期149-152,共4页Journal of Harbin Medical University

基　　金：黑龙江省教育厅科学技术研究项目(11531206)

摘　　要：目的探讨白细胞介素18(interleukin-18,IL-18)与2型糖尿病大血管病变的关系。方法用酶联免疫吸附法(enzyme linked immunosorbent assay,ELISA)分别检测30例健康对照者和60例2型糖尿病患者(其中单纯糖尿病者30例,合并大血管病变者30例)血清IL-18水平,并同时测定其他临床指标。结果糖尿病合并大血管病变组血清IL-18、血脂、血压水平明显高于正常对照组和单纯2型糖尿病患者;血清中IL-18与血压、体重指数(body mass index,BMI)、血脂、胰岛素抵抗指数(homeostasismodel of assessment for insulin resistence index,HOMA-IR)、病程、空腹血糖(fasting plasma glucose,FPG)呈正相关。结论 2型糖尿病存在高IL-18血症,在2型糖尿病大血管病变时更为显著。提示炎症参与了2型糖尿病及大血管合并症的发生、发展。IL-18可能是2型糖尿病大血管病变的危险因素和预测因子之一。Objective To investigate the relationship between the serum interleukin-18（IL-18） and type 2 diabetes mellitus with macroangiopathy.Methods The levels of serum IL-18 were determined by enzyme linked immunosorbent assay（ELISA） in 30 healthy controls and 60 cases with type 2 diabetic patients（including 30 cases with macroangiopathy and 30 cases without complications）.Other clinical parameters were also measured.Results The levels of IL-18,triglyceride（TG）,blood pressure（BP） were markedly elevated in type 2 diabetic macroangiopathy group than in type 2 diabetes mellitus without complications and normal control group.IL-18 was correlated positively with BP,body mass index（BMI）,TG,homeostasis model of assessment for insulin resistence index（HOMA-IR）,course,fasting plasma glucose（FPG）.Conclusion The levels of IL-18 are markedly elevated in type 2 diabetes mellitus especially in type 2 diabetes mellitus with macroangiopathy.It suggests that inflammation plays animportant role in the development of type 2 diabetes mellitus and macroangiopathy.IL-18 may be one risk factor and predictor for type 2 diabetic macroangiopathy.

关 键 词：白细胞介素18 2型糖尿病 动脉粥样硬化 大血管病变 

分 类 号：R587.1[医药卫生—内分泌]