枇杷花的研究进展及其药效评价思路的探讨  

Advances in studies on flower of Eriobotrya japonica and exploration on ideas for its efficacy evaluation

作　　者：孙苏逖[1] 孟宪丽[1] 李春雨[1] 王张[1] 

机构地区：[1]成都中医药大学,四川成都611137

出　　处：《现代药物与临床》2011年第3期199-202,共4页Drugs & Clinic

摘　　要：枇杷花具有重要的药用价值和开发潜力。近年来国内外相关研究主要集中在枇杷花的化学成分、提取和精制工艺、药理效应和应用开发等方面,但存在有效性评价方法不系统和有效剂量不明确等问题。在综述枇杷花化学成分、提取和精制工艺、药理作用的基础上,提出如下研究思路:基于传统用药经验,应用经典、快速的动物模型确定有效剂量范围,整合多致病因素、多模型动物和多药理效应的药效学评价体系,引入模式识别分析等统计学方法,综合评价枇杷花的镇咳有效性并研究其作用机制,以期为枇杷花的开发提供科学依据。Loquat flower （the flower of Eriobotryajaponica） possesses important medicinal application value and great potential for development. In recent years, the related studies about loquat flower have been focused on chemical composition, techniques of extraction and purification, pharmacological effects, and application development. Nevertheless, research problems are still existed. For example, the methods of the efficacy evaluation are not systemic and the effective dose is not definite. This paper puts forward some research ideas as following. Based on the experience of traditional medicine, the effective dose could be defined through some classical and rapid animal models. Meanwhile, by using the pharmacological evaluation system which integrates the multi causative factors, multi animal models, multi pharmacological effects, and the pattern recognition technology, the antitussive effect of loquat flower could be synthetically estimated, its mechanism of action studied, and scientific proofs to exploit loquat flower provided as the new part-used for medicine materials.

关 键 词：枇杷花 化学成分 药理作用 止咳 有效性评价 

分 类 号：R282.71[医药卫生—中药学]