丁基锂与氯化铜存在条件下仲胺偶联形成N-N键的新方法(英文)  

A new approach to N-N bond on homocoupling of secondary amines in the presence of butyl lithium and cupric chloride

作　　者：李宗耀[1,2] 李彪[1] 李春丽[1] 王华[1] 

机构地区：[1]河南大学特种功能材料教育部重点实验室,河南开封475004 [2]河南省煤业化工集团研究院,河南郑州450046

出　　处：《化学研究》2011年第4期1-4,共4页Chemical Research

基　　金：This research was supported by the NSFC(20572015,20672028);Programfor Young Excellent Talents in Henan Universities and Foundation of Henan University(07YB2R006);Programof Henan University(SBGJ090506)

摘　　要：报道了以仲胺反应底物经丁基锂夺去活性质子,无水氯化铜氧化偶联形成N-N键的新方法.共完成了11种底物尝试,所得产物肼的产率在17%~76%之间.相关合成方法是一种从仲胺制备对称取代肼的高效合成方法.A series of symmetric tetrasubstituted hydrazines was prepared in a yield of 17%-76% by way of homocoupling of secondary amines as the substrates in the presence of butyl lithium and cupric chloride（n-BuLi/CuCl2）,where the active protons of the substrates were captured by n-BuLi,and N-N bond was formed via oxidation coupling of anhydrous CuCl2.Totally 11 substrates were successfully employed.This protocol provides an efficient route to synthesizing symmetric tetrasubstituted hydrazine from secondary amines.

关 键 词：仲胺 丁基锂 氯化铜 氧化偶联 四取代肼 新方法 

分 类 号：O627.12[理学—有机化学]