聚异戊二烯基三胺的合成及生理活性评价  

Synthesis of polyisoprenylamines and evaluation of their biological activity

作　　者：甘莹[1] 王朝义[1] 何利华[1] 王超杰[1] 赵瑾[1] 

机构地区：[1]河南大学河南省天然药物与免疫工程重点实验室,河南开封475004

出　　处：《化学研究》2011年第4期5-6,共2页Chemical Research

基　　金：国家自然科学基金资助项目(20872027;90913001);河南省科技厅重点科技攻关项目(072102270004;102102310195);河南大学省部共建资助项目(SBGJ090518)

摘　　要：设计、合成了一系列聚异戊二烯基三胺化合物,目标化合物结构均经过核磁共振谱、质谱及元素分析确认;利用MTT法测试了目标化合物对人白血病细胞K562和人肝癌细胞Bel-7402的体外抗肿瘤活性.结果表明,目标化合物对两种肿瘤细胞的生长均有较强的抑制活性.A series of polyisoprenylamines were designed and synthesized,and their structures were confirmed by means of nuclear magnetic resonance spectroscopy,mass spectrometry（MS） and element analysis.In the meantime,MTT assay was adopted to evaluate the prelimilary antitumor activity of as-synthesized products against human leukemia cell（K562） and hepatocarcinoma cell（Bel-7402）.It was found that target compounds possessed potent inhibitory activity against tumor cells K562 and Bel-7402.

关 键 词：多聚异戊二烯基三胺 合成 生理活性 

分 类 号：O625.6[理学—有机化学]