骨转换生化标志物在DM2并发骨质疏松的临床应用价值  

The Value of the Clinical Application of Biochemical Marker of Bone Turnover in Patients Type 2 Diabetes Complicated with Osteoporosis

作　　者：栾玉芬[1] 范光磊[1] 许强 万仁明[1] 杨其贤[1] 徐龙宝[1] 

机构地区：[1]南京医科大学附属常州市第二人民医院核医学科,213003 [2]江苏省常州市武进区牛塘社区卫生服务中心,213163

出　　处：《放射免疫学杂志》2011年第3期316-317,共2页Journal of Radioimmanology

摘　　要：目的:探讨骨转换生化标志物在2型糖尿病(DM2)患者并发骨质疏松的早期诊断价值。方法:选择112例DM2患者,根据受试者的骨密度值分为骨质疏松组和非骨质疏松组,对比两组DM2患者的总Ⅰ型前胶原氨基端延长肽(TPINP)、Ⅰ型胶原羧基端肽β特殊序列(β-CTx)、甲状旁腺素(PTH)和血清钙(Ca2+)指标之间的差异。结果:骨质疏松组与非骨质疏松组相比较,TPINP及β-CTx差异有统计学意义(P<0.05);PTH、血清Ca2+值差异无显著性。结论:联合应用TPINP、β-CTx有助于DM2患者骨质疏松症的诊断。Objective To explore the value of the application of biochemical marker of bone turnover in the early diagnosis of osteoporosis（OP） in patients with type 2 diabetes（DM2）.Methods 112 patients with type 2 diabetes were studied,according to their bone mineral density（BMD） values,patients were divided into OP group and none-OP group.Then compared differences in serum total procollagen type Ⅰ amino-terminal propeptide（TPINP）,β-isomerized carboxyterminal propeptide（β-CTx）,parathyroid hormone（PTH） and serum calcium（Ca2＋）.Results Compared with those in non-OP group,patients in the OP group had higher TPINP and β-CTx,which were significantly different according to t-test（P0.05）.The PTH and Ca2＋ values in the two groups were no neal difference.Conclusion The combined application of total procollagen typeⅠamino-terminal propeptide,β-isomerized carboxyterminal propeptide is helpful for the diagnosis of osteoporosis in patients with type 2 diabetes.

关 键 词：骨转换标志物 2型糖尿病 骨质疏松 

分 类 号：R681[医药卫生—骨科学]