Synthesis and Crystal Structure of (3R,4R)-5-(2,4-Dichlorobenzoyl)-4-(4-nitrophenyl)-6-(phenylamino)-3,4-dihydro-2H-thiopyran-3-carbonitrile  

作　　者：文丽荣 王丽娟 李明 

机构地区：[1]Key Laboratory of Eco-Chemical Engineering,Ministry of Education,College of Chemistry and Molecular Engineering,Qingdao University of Science and Technology

出　　处：《Chinese Journal of Structural Chemistry》2011年第6期867-871,共5页结构化学（英文）

基　　金：supported by the National Natural Science Foundation of China (No. 20872074 and 21072110);the Natural Science Foundation of Shandong Province (No. Z2008B03 and ZR2010BM007);the Doctoral Foundation of Qingdao University of Science and Technology

摘　　要：The title compound（C25H16Cl2N3O3S）,as a thiopyran derivative,has been synthe-sized by the cyclization of an organic intermediate obtained from Baylis-Hillman adducts with a β-aroylthioamide using copper（I） salt as the catalyst.The crystal belongs to the monoclinic system,space group P21/c with a = 13.668（3）,b = 8.4803（17） c = 21.999（4） ,β = 113.57（3）°,V = 2337.2（10） 3,Z = 4,Mr = 510.38,Dc = 1.451 g/cm3,μ = 0.401 mm-1,F（000） = 1048,the final R = 0.0487 and wR = 0.1079 for 3678 observed reflections with I〉 2σ（I）.The title compound（C25H16Cl2N3O3S）,as a thiopyran derivative,has been synthe-sized by the cyclization of an organic intermediate obtained from Baylis-Hillman adducts with a β-aroylthioamide using copper（I） salt as the catalyst.The crystal belongs to the monoclinic system,space group P21/c with a = 13.668（3）,b = 8.4803（17） c = 21.999（4） ,β = 113.57（3）°,V = 2337.2（10） 3,Z = 4,Mr = 510.38,Dc = 1.451 g/cm3,μ = 0.401 mm-1,F（000） = 1048,the final R = 0.0487 and wR = 0.1079 for 3678 observed reflections with I〉 2σ（I）.

关 键 词：CuI-L-proline-Cs2CO3 thiopyran derivative β-aroylthioamide synthesis crystal structure 

分 类 号：O621.3[理学—有机化学]