非那雄胺和米诺地尔治疗雄激素性秃发的临床研究  

The clinical research of finasteride and minoxidil for treating androgenic alopecia

作　　者：王羿婷[1] 李子海[1] 尹晓晴[1] 储小燕[1] 李中明[1] 许文荣[1] 吴瑾[1] 陈蕾[1] 关宁宁[1] 李磊磊[1] 孙蔚凌[1] 范卫新[1] 

机构地区：[1]南京医科大学第一附属医院皮肤性病科,江苏南京210029

出　　处：《临床皮肤科杂志》2011年第7期387-390,共4页Journal of Clinical Dermatology

摘　　要：目的:观察非那雄胺、5%米诺地尔及两者联合治疗男性雄激素性秃发(AGA)的疗效。方法:男性AGA患者共248例,分为3组,分别外用5%米诺地尔、口服非那雄胺,及米诺地尔与非那雄胺联合治疗,随访12个月,每次随访时拍照并进行分级和评分,同时观察和记录不良反应。结果:用药6个月、12个月时,联合用药组疗效优于口服组及外用组。口服组、联合用药组的疗效与疗程呈正相关,各组患者的疗效与脱发严重程度相关,与发病年龄和家族史无相关性。结论:联合治疗与单独口服非那雄胺、单独外用米诺地尔相比,起效快,疗效好;且疗程长达1年,联合用药的疗效优于单独用药。Objective： To observe the efficacy of finasteride, 5% minoxidil alone and their combination on the treatment of male androgenic alopeeia （AGA）. Methods： Three groups were designed for male AGA patients： the 5% minoxidil topical therapy group, the finasteride oral treatment group, and the combined application group. The follow-up period was twelve months and upon each follow-up visit, the experimental subjects were being taken photos for record, assessed and classified accordingly. Results： After six to twelve months of drug administration, the combined application group demonstrated a more satisfying clinical effect than that of the oral therapy group or the topical group. In addition, the positive correlations between the treatment course and the therapeutic effectiveness were found in the male AGA oral treatment group, the combined ap- plication group. The therapeutic effect of medication, as demonstrated by patients of the above groups, was related to the de- gree of alopecia severity but not to their family history and alopecia onset age. Conclusion： The results of the study indi- cate that the combined medication has a shorter effectuated time and more significant clinical effect comparing to that of o- rally intake fiansteride alone or topically applying finasteride alone. Comparing to both cases of single-drug groups, combined application treatment group demonstrated better curative effectiveness.

关 键 词：雄激素性秃发 非那雄胺 米诺地尔 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]