药物诱发天疱疮6例分析  

Analysis of 6 cases of drug-induced pemphigus

作　　者：冯素英[1] 周武庆[1] 靳培英[1] 

机构地区：[1]中国医学科学院、北京协和医学院皮肤病研究所,江苏南京210042

出　　处：《临床皮肤科杂志》2011年第7期396-399,共4页Journal of Clinical Dermatology

基　　金：国家级公益性科研院所基本科研业务专项基金(yz-07-2);北京协和医学院青年科研基金资助项目

摘　　要：目的:研究药物诱发天疱疮的临床和实验室检查特点和规律。方法:采用直接免疫荧光、ELISA方法研究6例药物诱发天疱疮的特点,并用20例特发性天疱疮做对照。结果:药物诱发天疱疮多有瘙痒,口腔溃疡发生率低;5例表现为落叶型天疱疮(Dsgl IgG阳性),血清中抗体滴度低,对小剂量糖皮质激素敏感,预后好;66.67%患者外周血清中Dsgl IgA阳性,经治疗后该抗体消失;1例利福平诱发者表现为寻常型天疱疮。结论:对于天疱疮患者应注意药物诱发因素。Objective： To study clinical and laboratory characteristics and rules of drug-induced pemphigus. Methods： Using direct immunofluorescenee, indirect immunofluorescence and ELISA to research the characteristics of 6 patients with drug-in- duced pemphigus and compared with those of 20 cases of idiopathic pemphigus. Results： Drug-induced pemphigus had high incidence of itching and low incidence of oral ulcers. Five cases （83.33%） of pemphigus were showed as pemphigus folicaeus （Dsgl IgG positive）, they contained lower Dsg antibody titer in serum and were sensitive to small amount of glucocorticoid. Dsgl IgA was positive in peripheral serum of 4 cases （66.67%）, and the antibody disappeared after succeeding treatment. One case of rifampin-induced pemphigus was showed as pemphigus vulgaris. Conclusion： One should pay more attention to drug-induced factors in patients with pemphigus.

关 键 词：天疱疮 药物诱发 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]