皮肤异色病样淀粉样变性免疫荧光及电镜观察  

The observation with immunofluorence and electron microscopy for a case of poikiloderma-like cutaneous amyloidosis

作　　者：晏洪波[1] 罗颖[1] 梁文[1] 李德忠[2] 

机构地区：[1]中国人民解放军广州军区武汉总医院皮肤性病科,湖北武汉430070 [2]中国人民解放军广州军区武汉总医院医学实验科,湖北武汉430070

出　　处：《临床皮肤科杂志》2011年第7期413-416,共4页Journal of Clinical Dermatology

摘　　要：报告1例皮肤异色病样淀粉样变性。患者男,40岁。四肢、躯干色素沉着和色素减退相间,伴苔藓样丘疹及毛细血管扩张20年,无自觉症状。全身皮损于夏季加重且可出现水疱。家族中无类似疾病史,父母系近亲结婚(表兄妹)。皮损组织病理检查示真皮乳头内有红色团块样均质性物质,结晶紫染色阳性。直接免疫荧光(DIF)检查:表皮基膜带及表皮细胞问IgG、IgM、IgA、C3均阴性,真皮乳头及真皮浅层可见大量团块状物质沉积,其中IgG标记可见较强荧光。电镜检查:真皮乳头及真皮浅层可见大量团块状物质沉积与基膜带及基底细胞关系密切。A case of poikiloderma-like cutaneous amyloidosis is reported. A 40-year-old male presented with asymptomatic poikilodermatous skin lesion, lichenoid papules, blisters and telangiectases on the limbs and trunk for 20 years. All lesions were exacerbated and tense blisters occurred in summer. There was no same case in the family. Parents were married con- sanguineously （cousins）. Skin biopsy revealed eosinophilic amorphous globules below the basement membrane zone and dermal papillae, It showed positive staining results with gentian violet. Direct immunofluoreseenee （DIF） test showed： IgG, IgM, IgA and C3 were negative in basement membrane zone and among epidermal cells. In dermal papillae and upper dermis there was a great deal of depositions of globular materials with a rather strong IgG fluorescent marker. Electron microscopy examination revealed a lot of globular materials deposited in dermal papillae and upper dermis, which closely connected to basal cells and the basement membrane zone.

关 键 词：淀粉样变性 皮肤异色病 水疱 免疫荧光 电镜 

分 类 号：R758.5[医药卫生—皮肤病学与性病学]